1. GPCR/G Protein
  2. Endothelin Receptor

BQ-123 (Synonyms: BQ 123; BQ123)

Cat. No.: HY-12378 Purity: 98.39%
Data Sheet SDS Handling Instructions

BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) .

For research use only. We do not sell to patients.
BQ-123 Chemical Structure

BQ-123 Chemical Structure

CAS No. : 136553-81-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO $537 In-stock
1 mg $100 In-stock
5 mg $400 In-stock
10 mg $700 In-stock
50 mg   Get quote  
100 mg   Get quote  

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Description

BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model. 2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. 3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.

Clinical Trial
NCT Number Sponsor Condition Start Date Phase
NCT02987465 Cambridge University Hospitals NHS Foundation Trust|GlaxoSmithKline Cardiovascular Diseases|Chronic Kidney Disease February 20, 2017
NCT00586820 Mayo Clinic Myocardial Reperfusion Injury May 2005 Phase 2
NCT00759408 Brigham and Women's Hospital Pulmonary Hypertension February 1999 Phase 2
NCT00745693 University of Edinburgh|Umeå University Coronary Disease March 2008
NCT01658410 Medical University of Vienna Coronary Artery Disease|Aorto-coronary Bypass Grafting July 2012 Phase 2
NCT00502528 Medical University of Vienna ST-Elevation Myocardial Infarction May 2007 Phase 2
NCT02086253 University Hospital, Rouen Healthy Conditions February 2014
NCT00115583 Brigham and Women's Hospital Atherosclerosis, Coronary November 1998
NCT00915070 Medical University of Vienna Healthy October 2010
NCT02124824 VA Office of Research and Development|University of Utah Heart Failure September 1, 2014 Early Phase 1
NCT00427232 Medical University of Vienna Coronary Vessels|Endothelins|Vascular Resistance May 2003 Phase 1
NCT00722215 University of Edinburgh|British Heart Foundation Chronic Kidney Disease|Proteinuria May 2006 Phase 1
NCT02966665 Russell Richardson|University of Utah Chronic Obstructive Pulmonary Disease|Pulmonary Artery Hypertension|Heart Failure|Hypertension September 2008 Phase 1
NCT01119417 Vanderbilt University|Vanderbilt University Medical Center Hypertension|Pure Autonomic Failure|Multiple System Atrophy May 2010 Phase 1
NCT02062346 University of Edinburgh|British Heart Foundation Vasculitis August 2016
NCT02987465 Cambridge University Hospitals NHS Foundation Trust|GlaxoSmithKline Cardiovascular Diseases|Chronic Kidney Disease February 20, 2017
NCT00586820 Mayo Clinic Myocardial Reperfusion Injury May 2005 Phase 2
NCT00759408 Brigham and Women's Hospital Pulmonary Hypertension February 1999 Phase 2
NCT00745693 University of Edinburgh|Umeå University Coronary Disease March 2008
NCT01658410 Medical University of Vienna Coronary Artery Disease|Aorto-coronary Bypass Grafting July 2012 Phase 2
NCT00502528 Medical University of Vienna ST-Elevation Myocardial Infarction May 2007 Phase 2
NCT02086253 University Hospital, Rouen Healthy Conditions February 2014
NCT00115583 Brigham and Women's Hospital Atherosclerosis, Coronary November 1998
NCT00915070 Medical University of Vienna Healthy October 2010
NCT02124824 VA Office of Research and Development|University of Utah Heart Failure September 1, 2014 Early Phase 1
NCT00427232 Medical University of Vienna Coronary Vessels|Endothelins|Vascular Resistance May 2003 Phase 1
NCT00722215 University of Edinburgh|British Heart Foundation Chronic Kidney Disease|Proteinuria May 2006 Phase 1
NCT02966665 Russell Richardson|University of Utah Chronic Obstructive Pulmonary Disease|Pulmonary Artery Hypertension|Heart Failure|Hypertension September 2008 Phase 1
NCT01119417 Vanderbilt University|Vanderbilt University Medical Center Hypertension|Pure Autonomic Failure|Multiple System Atrophy May 2010 Phase 1
NCT02062346 University of Edinburgh|British Heart Foundation Vasculitis August 2016
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References
M.Wt

610.7

Formula

C₃₁H₄₂N₆O₇

CAS No.

136553-81-6

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

Solvent & Solubility

DMSO: ≥ 34 mg/mL

* "<1 mg/mL" means slightly soluble or insoluble. "≥" means soluble, but saturation unknown.

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Product Name:
BQ-123
Cat. No.:
HY-12378
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