1. GPCR/G Protein
  2. Endothelin Receptor

BQ-123 

Cat. No.: HY-12378 Purity: 98.39%
Handling Instructions

BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) .

For research use only. We do not sell to patients.

BQ-123 Chemical Structure

BQ-123 Chemical Structure

CAS No. : 136553-81-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 537 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
1 mg USD 100 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
5 mg USD 400 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
10 mg USD 700 In-stock
Stock in Sweden
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

BQ-123 is an ETA endothelin receptor antagonist (Ki values are 1.4 and 1500 nM at ETA and ETB receptors respectively) . 1) Reduces ischemia-induced ventricular arrhythmias in a rat model. 2) BQ-123 prevents LPS-induced preterm birth in mice via the induction of uterine and placental IL-10. 3) The reference for animal injections is 6.7 mg/kg. 4) BQ-123 decreased IL-1β and TNFα in the placenta while also decreasing transcription of ET-1 in the uterus.

Clinical Trial
Solvent & Solubility
In Vitro: 

DMSO : ≥ 34 mg/mL (55.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6375 mL 8.1873 mL 16.3747 mL
5 mM 0.3275 mL 1.6375 mL 3.2749 mL
10 mM 0.1637 mL 0.8187 mL 1.6375 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

610.7

Formula

C₃₁H₄₂N₆O₇

CAS No.

136553-81-6

SMILES

O=C(N[[email protected]](C(N(CCC1)[[email protected]]1([H])C2=O)=O)([H])CC(O)=O)[[email protected]](NC([[email protected]@H](NC([[email protected]](N2)C(C)C)=O)CC(C)C)=O)CC3=CNC4=CC=CC=C34

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BQ-123
Cat. No.:
HY-12378
Quantity:

BQ-123

Cat. No.: HY-12378