1. Anti-infection
    GPCR/G Protein
  2. Bacterial
    Endothelin Receptor
    Antibiotic
  3. Sulfisoxazole

Sulfisoxazole (Synonyms: Sulfafurazole)

Cat. No.: HY-B0323 Purity: 99.96%
Handling Instructions

Sulfisoxazole (Sulfafurazole), an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A.

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Sulfisoxazole Chemical Structure

Sulfisoxazole Chemical Structure

CAS No. : 127-69-5

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Description

Sulfisoxazole (Sulfafurazole), an endothelin receptor antagonist, is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2][3].

In Vitro

The sulfanilamide antibacterial agent sulfisoxazole was found to be a good endothelin receptor antagonist (IC50's of 0.60 microM and 22 microM for the ETA and ETB receptors, respectively) [1]. Sulfisoxazole is used to treat or prevent infections in many different parts of the body. It belongs to the group of medicines known as sulfonamide antibiotics. It works by preventing the growth of bacteria[3].

Molecular Weight

267.30

Formula

C₁₁H₁₃N₃O₃S

CAS No.

127-69-5

SMILES

O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 150 mg/mL (561.17 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.7411 mL 18.7056 mL 37.4112 mL
5 mM 0.7482 mL 3.7411 mL 7.4822 mL
10 mM 0.3741 mL 1.8706 mL 3.7411 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (9.35 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 99.96%

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Keywords:

SulfisoxazoleSulfafurazoleBacterialEndothelin ReceptorAntibioticInhibitorinhibitorinhibit

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