Sulfisoxazole diethanolamine
Based on 5 publication(s) in Google Scholar
Sulfisoxazole (Sulfafurazole) diethanolamine is an endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole diethanolamine is a sulfonamide antibacterial with an oxazole substituent. Sulfisoxazole diethanolamine inhibits breast cancer exosome release by targeting endothelin receptor A.
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- CAS No.: 4299-60-9
- Formula: C15H24N4O5S
- Molecular Weight:372.44
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Publications Citing Use of MedChemExpress (MCE) Sulfisoxazole diethanolamine
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Biological Activity
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ETA 0.60 μM (IC50) |
ETB 22 μM (IC50) |
Chemical Information
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CAS No. 4299-60-9
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Molecular Weight 372.44
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Formula C15H24N4O5S
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SMILES
O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O.OCCNCCO
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Synonyms
Sulfafurazole diethanolamine
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (5)
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Journal Impact Factor
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Most Recent
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Adv Sci (Weinh)
Local Exosome Inhibition Potentiates Mild Photothermal Immunotherapy Against Breast Cancer. [Abstract]2025 Jan;12(2):e2406328. PMID: 39574346 -
ACS Environ Au
Machine Learning-Assisted Recognition of Environmental Sulfur-Containing Chemicals in Nontargeted Mass Spectrometry Analysis of Inadequate Mass Resolution. [Abstract]2025 Aug 5;5(6):573-582. PMID: 41277996 -
Anal Chem
Exposome-Scale Investigation of Cl-/Br-Containing Chemicals Using High-Resolution Mass Spectrometry, Multistage Machine Learning, and Cloud Computing. [Abstract]2025 Jun 3;97(21):11099-11109. PMID: 40401576 -
Biology (Basel)
Repurposing of Antibiotic Sulfisoxazole Inhibits Lipolysis in Pre-Clinical Model of Cancer-Associated Cachexia. [Abstract]2021 Jul 22;10(8):700. PMID: 34439933 -
Chemosphere
Sustainable production of Fe-doped MnO2 nanoparticles for accelerated tetracycline antibiotic detoxification. [Abstract]2023 Dec:344:140353. PMID: 37797898
Purity & Documentation
References
[1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34. [Content Brief]
[2]. Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sulfisoxazole diethanolamine Related Classifications
HY-B0323A Related Classifications
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