127-69-5
Chemical Structure
Sulfisoxazole
Synonym(s): Sulfafurazole
- CAS No.: 127-69-5
- Formula:C11H13N3O3S
- Molecular Weight:267.30
IUPAC Name: 4-amino-N-(3,4-dimethylisoxazol-5-yl)benzenesulfonamide
InChIKey: NHUHCSRWZMLRLA-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C(N)C=C1)(NC2=C(C)C(C)=NO2)=O
Biological Activity: Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
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Sulfisoxazole | 99.90% | Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A. | ||||||||||||||||||||
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Sulfisoxazole (Standard) | 99.99% | Sulfisoxazole (Standard) is the analytical standard of Sulfisoxazole. This product is intended for research and analytical applications. Sulfisoxazole (Sulfafurazole) is an orally active endothelin receptor antagonist with IC50 values of 0.60 μM and 22 μM against endothelin receptor A and endothelin receptor B, respectively. Sulfisoxazole is a sulfonamide antibacterial agent with an oxazole substituent. Sulfisoxazole inhibits breast cancer exosome release by targeting endothelin receptor A. | ||||||||||||||||||||
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Sulfisoxazole 100 µg/mL in methanol | Sulfisoxazole 100 μg/mL in methanol (Sulfafurazole 100 μg/mL in methanol) is a sulfonamide antimicrobial compound. | |||||||||||||||||||||
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- [1]. Chan, M.F., et al., Identification of a new class of ETA selective endothelin antagonists by pharmacophore directed screening. Biochem Biophys Res Commun, 1994. 201(1): p. 228-34. [Content Brief]
- [2]. Im EJ, et al. Sulfisoxazole inhibits the secretion of small extracellular vesicles by targeting the endothelin receptor A. Nat Commun. 2019 Mar 27;10(1):1387. [Content Brief]
