2. Disease Areas
  3. Neurological, Eye or Ear Disease Blood or Cardio-cerebrovascular Disease
  4. Cerebrovascular Disease
  5. Aneurysm

Aneurysm

Aneurysm is a bulge in the wall of an artery. Aneurysms form when there’s a weak area in the artery wall. Untreated aneurysms can burst open, leading to internal bleeding. They can also cause blood clots that block the flow of blood in your artery. Depending on the location of the aneurysm, a rupture or clot can be life-threatening.

References:

Aneurysm (3):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-B1451
    Imidapril hydrochloride 89396-94-1 99.91%
    Imidapril hydrochloride (TA-6366) is an orally active dual inhibitor of angiotensin-converting enzyme (ACE) and MMP-9. Imidapril hydrochloride inhibits lipopolysaccharide-induced phosphorylation of c-Jun, MKK4 and JNK in monocytes, and downregulates the production of specific inflammatory factors such as TNF-α and IP-10, thereby exerting anti-inflammatory activity. Imidapril hydrochloride also effectively ameliorates mesangial expansion and reduces urinary albumin excretion by inhibiting angiotensin AngII production, lowering glomerular pressure and oxidative stress, thus delaying disease progression. Imidapril hydrochloride can also directly bind to the active site of MMP-9 to inhibit gelatinase activity, and suppress the enlargement of cerebral aneurysms without altering systemic blood pressure. Imidapril hydrochloride is widely applicable to related studies on autoimmune glomerulonephritis, diabetic nephropathy, cerebral aneurysms and other conditions.
    Imidapril hydrochloride
  • HY-175599
    Z6466608628 2869183-63-9
    Z6466608628 is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 functionally recruits PPIL4 to CRBN, induces CRL4CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 can be used for the research of intracranial aneurysms.
    Z6466608628
  • HY-175599A
    Z6466608628 hydrochloride 99.25%
    Z6466608628 hydrochloride is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 hydrochloride functionally recruits PPIL4 to CRBN, induces CRL4CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 hydrochloride can be used for the research of intracranial aneurysms[1].
    Z6466608628 hydrochloride