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  3. Molecular Glues
  4. Z6466608628

Z6466608628 is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 functionally recruits PPIL4 to CRBN, induces CRL4CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 can be used for the research of intracranial aneurysms.

For research use only. We do not sell to patients.

Z6466608628

Z6466608628 Chemical Structure

CAS No. : 2869183-63-9

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Z6466608628 Related Antibodies

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Description

Z6466608628 is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 functionally recruits PPIL4 to CRBN, induces CRL4CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 can be used for the research of intracranial aneurysms[1].

In Vitro

Z6466608628 (10 nM-100 μM; 1 h) potently induces ternary complex formation between recombinant human CRBN-DDB1ΔB and human PPIL4 with an EC50 of 0.34 μM[1].
Z6466608628 (1.66-3.33 μM; 1 h) selectively recruits human PPIL4 and its binding partner DHX40 to recombinant human CRBN-DDB1ΔB in Kelly cell lysate[1].
Z6466608628 (1 μM; 5 h) induces selective, modest downregulation of PPIL4 in MOLT4 cells[1].
Z6466608628 (0.1-10 μM; 5 H) causes dose-dependent depletion of PPIL4 protein in MOLT4 cells, with incomplete degradation observed at 10 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z6466608628 Related Antibodies
Molecular Weight

404.46

Formula

C23H24N4O3
CAS No.
SMILES

O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3C4=CC=C(C=C4)N5CCNCC5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Z6466608628 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z64666086282869183-63-9Z 6466608628Z-6466608628Molecular GluesspliceosomeDHX40Kelly cell lysateMOLT4 cellsPPIL4CRL4CRBNubiquitylationintracranial aneurysmsDDB1ΔBCRBNInhibitorinhibitorinhibit

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