Z6466608628 hydrochloride

Name: Z6466608628 hydrochloride
Brand: MedChemExpress
SKU: HY-175599A
Rating: 4.5 (0 reviews)

Cat. No.: HY-175599A Purity: 99.25%: Data Sheet
COA

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Handling Instructions
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Z6466608628 hydrochloride is a selective PPIL4 molecular glue degrader with human PPIL4 EC₅₀ values of 0.34 µM. Z6466608628 hydrochloride functionally recruits PPIL4 to CRBN, induces CRL4^CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 hydrochloride can be used for the research of intracranial aneurysms^[1].

For research use only. We do not sell to patients.

Z6466608628 hydrochloride Chemical Structure

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of Z6466608628 hydrochloride:

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Z6466608628 (10 nM-100 μM; 1 h) hydrochloride potently induces ternary complex formation between recombinant human CRBN-DDB1ΔB and human PPIL4 with an EC₅₀ of 0.34 μM^[1].
Z6466608628 (1.66-3.33 μM; 1 h) hydrochloride selectively recruits human PPIL4 and its binding partner DHX40 to recombinant human CRBN-DDB1ΔB in Kelly cell lysate^[1].
Z6466608628 (1 μM; 5 h) hydrochloride induces selective, modest downregulation of PPIL4 in MOLT4 cells^[1].
Z6466608628 (0.1-10 μM; 5 H) hydrochloride causes dose-dependent depletion of PPIL4 protein in MOLT4 cells, with incomplete degradation observed at 10 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:	MOLT4 cells
Concentration:	0.1 μM; 1 μM; 5 μM; 10 μM
Incubation Time:	5 h
Result:	Caused dose-dependent depletion of PPIL4 protein. Caused incomplete degradation at 10 μM.

Molecular Weight

440.92

Formula

C₂₃H₂₅ClN₄O₃

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3C4=CC=C(C=C4)N5CCNCC5.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (226.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2680 mL	11.3399 mL	22.6798 mL
5 mM	0.4536 mL	2.2680 mL	4.5360 mL
10 mM	0.2268 mL	1.1340 mL	2.2680 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.25%

Select Batch:

Data Sheet (275 KB) SDS (252 KB)

COA (253 KB) HNMR (291 KB) LCMS (334 KB)

Handling Instructions (2659 KB)

References

[1]. Baek K, et al. Unveiling the hidden interactome of CRBN molecular glues. Nat Commun. 2025 Jul 24;16(1):6831. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2680 mL	11.3399 mL	22.6799 mL	56.6996 mL
	5 mM	0.4536 mL	2.2680 mL	4.5360 mL	11.3399 mL
	10 mM	0.2268 mL	1.1340 mL	2.2680 mL	5.6700 mL
	15 mM	0.1512 mL	0.7560 mL	1.5120 mL	3.7800 mL
	20 mM	0.1134 mL	0.5670 mL	1.1340 mL	2.8350 mL
	25 mM	0.0907 mL	0.4536 mL	0.9072 mL	2.2680 mL
	30 mM	0.0756 mL	0.3780 mL	0.7560 mL	1.8900 mL
	40 mM	0.0567 mL	0.2835 mL	0.5670 mL	1.4175 mL
	50 mM	0.0454 mL	0.2268 mL	0.4536 mL	1.1340 mL
	60 mM	0.0378 mL	0.1890 mL	0.3780 mL	0.9450 mL
	80 mM	0.0283 mL	0.1417 mL	0.2835 mL	0.7087 mL
	100 mM	0.0227 mL	0.1134 mL	0.2268 mL	0.5670 mL