Z6466608628 hydrochloride
Based on 1 Customer Validation
Z6466608628 hydrochloride is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 hydrochloride functionally recruits PPIL4 to CRBN, induces CRL4CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 hydrochloride can be used for the research of intracranial aneurysms[1].
For research use only. We do not sell to patients.
- Purity: 99.25%
- Formula: C23H25ClN4O3
- Molecular Weight:440.92
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Z6466608628 (10 nM-100 μM; 1 h) hydrochloride potently induces ternary complex formation between recombinant human CRBN-DDB1ΔB and human PPIL4 with an EC50 of 0.34 μM[1].
Z6466608628 (1.66-3.33 μM; 1 h) hydrochloride selectively recruits human PPIL4 and its binding partner DHX40 to recombinant human CRBN-DDB1ΔB in Kelly cell lysate[1].
Z6466608628 (1 μM; 5 h) hydrochloride induces selective, modest downregulation of PPIL4 in MOLT4 cells[1].
Z6466608628 (0.1-10 μM; 5 H) hydrochloride causes dose-dependent depletion of PPIL4 protein in MOLT4 cells, with incomplete degradation observed at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:MOLT4 cells
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Concentration:0.1 μM; 1 μM; 5 μM; 10 μM
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Incubation Time:5 h
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Result:Caused dose-dependent depletion of PPIL4 protein.
Caused incomplete degradation at 10 μM.
Chemical Information
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Appearance Solid
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Molecular Weight 440.92
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Formula C23H25ClN4O3
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Color Off-white to light yellow
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SMILES
O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3C4=CC=C(C=C4)N5CCNCC5.Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : 100 mg/mL (226.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2680 mL | 11.3399 mL | 22.6799 mL | 56.6996 mL |
| 5 mM | 0.4536 mL | 2.2680 mL | 4.5360 mL | 11.3399 mL | |
| 10 mM | 0.2268 mL | 1.1340 mL | 2.2680 mL | 5.6700 mL | |
| 15 mM | 0.1512 mL | 0.7560 mL | 1.5120 mL | 3.7800 mL | |
| 20 mM | 0.1134 mL | 0.5670 mL | 1.1340 mL | 2.8350 mL | |
| 25 mM | 0.0907 mL | 0.4536 mL | 0.9072 mL | 2.2680 mL | |
| 30 mM | 0.0756 mL | 0.3780 mL | 0.7560 mL | 1.8900 mL | |
| 40 mM | 0.0567 mL | 0.2835 mL | 0.5670 mL | 1.4175 mL | |
| 50 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1340 mL | |
| 60 mM | 0.0378 mL | 0.1890 mL | 0.3780 mL | 0.9450 mL | |
| 80 mM | 0.0283 mL | 0.1417 mL | 0.2835 mL | 0.7087 mL | |
| 100 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.5670 mL |
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