Z6466608628 hydrochloride
Based on 1 Customer Validation
Z6466608628 hydrochloride is a selective PPIL4 molecular glue degrader with human PPIL4 EC50 values of 0.34 µM. Z6466608628 hydrochloride functionally recruits PPIL4 to CRBN, induces CRL4CRBN-mediated ubiquitylation and degradation of PPIL4. Z6466608628 hydrochloride can be used for the research of intracranial aneurysms[1].
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 99.25%
- 分子式: C23H25ClN4O3
- 分子量:440.92
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保管条件:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
体外実験
Z6466608628 (10 nM-100 μM; 1 h) hydrochloride potently induces ternary complex formation between recombinant human CRBN-DDB1ΔB and human PPIL4 with an EC50 of 0.34 μM[1].
Z6466608628 (1.66-3.33 μM; 1 h) hydrochloride selectively recruits human PPIL4 and its binding partner DHX40 to recombinant human CRBN-DDB1ΔB in Kelly cell lysate[1].
Z6466608628 (1 μM; 5 h) hydrochloride induces selective, modest downregulation of PPIL4 in MOLT4 cells[1].
Z6466608628 (0.1-10 μM; 5 H) hydrochloride causes dose-dependent depletion of PPIL4 protein in MOLT4 cells, with incomplete degradation observed at 10 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:MOLT4 cells
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Concentration:0.1 μM; 1 μM; 5 μM; 10 μM
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Incubation Time:5 h
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Result:Caused dose-dependent depletion of PPIL4 protein.
Caused incomplete degradation at 10 μM.
化学情報
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性状 Solid
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分子量 440.92
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分子式 C23H25ClN4O3
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Color Off-white to light yellow
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SMILES
O=C1CCC(C(N1)=O)N2CC3=C(C2=O)C=CC=C3C4=CC=C(C=C4)N5CCNCC5.Cl
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
溶剤 & 溶解度
体外:
DMSO : 100 mg/mL (226.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2680 mL | 11.3399 mL | 22.6799 mL | 56.6996 mL |
| 5 mM | 0.4536 mL | 2.2680 mL | 4.5360 mL | 11.3399 mL | |
| 10 mM | 0.2268 mL | 1.1340 mL | 2.2680 mL | 5.6700 mL | |
| 15 mM | 0.1512 mL | 0.7560 mL | 1.5120 mL | 3.7800 mL | |
| 20 mM | 0.1134 mL | 0.5670 mL | 1.1340 mL | 2.8350 mL | |
| 25 mM | 0.0907 mL | 0.4536 mL | 0.9072 mL | 2.2680 mL | |
| 30 mM | 0.0756 mL | 0.3780 mL | 0.7560 mL | 1.8900 mL | |
| 40 mM | 0.0567 mL | 0.2835 mL | 0.5670 mL | 1.4175 mL | |
| 50 mM | 0.0454 mL | 0.2268 mL | 0.4536 mL | 1.1340 mL | |
| 60 mM | 0.0378 mL | 0.1890 mL | 0.3780 mL | 0.9450 mL | |
| 80 mM | 0.0283 mL | 0.1417 mL | 0.2835 mL | 0.7087 mL | |
| 100 mM | 0.0227 mL | 0.1134 mL | 0.2268 mL | 0.5670 mL |
Z6466608628 hydrochloride 関連分類
HY-175599A 関連分類
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