1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Imidapril hydrochloride

Imidapril hydrochloride (Synonyms: TA-6366)

Cat. No.: HY-B1451 Purity: 99.95%
Handling Instructions

Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

For research use only. We do not sell to patients.

Imidapril hydrochloride Chemical Structure

Imidapril hydrochloride Chemical Structure

CAS No. : 89396-94-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg USD 360 In-stock
Estimated Time of Arrival: December 31
200 mg USD 504 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
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Description

Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

IC50 & Target

ACE

In Vitro

As a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

441.91

Formula

C₂₀H₂₈ClN₃O₆

CAS No.

89396-94-1

SMILES

O=C([[email protected]](CN1C)N(C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)C)=O)C1=O)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.15 mM; Need ultrasonic)

H2O : 50 mg/mL (113.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2629 mL 11.3145 mL 22.6290 mL
5 mM 0.4526 mL 2.2629 mL 4.5258 mL
10 mM 0.2263 mL 1.1315 mL 2.2629 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
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Keywords:

ImidaprilTA-6366TA6366TA 6366Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Product Name:
Imidapril hydrochloride
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HY-B1451
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