1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Imidapril hydrochloride

Imidapril hydrochloride (Synonyms: TA-6366)

Cat. No.: HY-B1451 Purity: 99.95%
Handling Instructions

Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

For research use only. We do not sell to patients.

Imidapril hydrochloride Chemical Structure

Imidapril hydrochloride Chemical Structure

CAS No. : 89396-94-1

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 79 In-stock
Estimated Time of Arrival: December 31
10 mg USD 72 In-stock
Estimated Time of Arrival: December 31
50 mg USD 216 In-stock
Estimated Time of Arrival: December 31
100 mg USD 360 In-stock
Estimated Time of Arrival: December 31
200 mg USD 504 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
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Based on 1 publication(s) in Google Scholar

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Description

Imidapril hydrochloride (TA-6366) is the hydrochloride salt of Imidapril, an angiotensin-converting enzyme (ACE) inhibitor with antihypertensive activity.

IC50 & Target

ACE

In Vitro

As a prodrug, Imidapril is converted by hydrolysis in the liver into its active form imidaprilat. Imidaprilat competitively binds to and inhibits ACE, thereby blocking the conversion of angiotensin I to angiotensin II. This prevents the potent vasoconstrictive actions of angiotensin II and results in vasodilation. Imidaprilat also decreases angiotensin II-induced aldosterone secretion by the adrenal cortex, which leads to an increase in sodium excretion and subsequently increases water outflow.

Clinical Trial
Molecular Weight

441.91

Formula

C₂₀H₂₈ClN₃O₆

CAS No.

89396-94-1

SMILES

O=C([[email protected]](CN1C)N(C([[email protected]@H](N[[email protected]](C(OCC)=O)CCC2=CC=CC=C2)C)=O)C1=O)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (113.15 mM; Need ultrasonic)

H2O : 50 mg/mL (113.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2629 mL 11.3145 mL 22.6290 mL
5 mM 0.4526 mL 2.2629 mL 4.5258 mL
10 mM 0.2263 mL 1.1315 mL 2.2629 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.66 mM); Clear solution

*All of the co-solvents are provided by MCE.
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Keywords:

ImidaprilTA-6366TA6366TA 6366Angiotensin-converting Enzyme (ACE)Inhibitorinhibitorinhibit

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Product Name:
Imidapril hydrochloride
Cat. No.:
HY-B1451
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