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  4. Deoxycorticosterone acetate

Deoxycorticosterone acetate  (Synonyms: 11-Deoxycorticosterone acetate; DOC acetate; Cortexone acetate)

Cat. No.: HY-B1472 Purity: 99.57%
COA Handling Instructions

Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria.

For research use only. We do not sell to patients.

Deoxycorticosterone acetate Chemical Structure

Deoxycorticosterone acetate Chemical Structure

CAS No. : 56-47-3

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Solid + Solvent
10 mM * 1 mL in DMSO
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Solid
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Description

Deoxycorticosterone acetate (DOCA) is an adrenocortin, acts as a precursor to aldosterone. Deoxycorticosterone acetate is a mineralocorticoid receptor agonist. Deoxycorticosterone acetate can cause severe renal injury, including inflammation, fibrosis, glomerular damage, and proteinuria[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

Deoxycorticosterone acetate (2.5 mg/d; s.c. implantation; 42 d; 2 mg/d Tamoxifen (HY-13757A) pre-treatment) induces hypertension by increasing blood pressure and cardiac hypertrophy in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MR (mineralocorticoid receptor) mutant mice (MRCdh5Cre) and MR wild-type mice (MRwild-type) treated with unilateral nephrectomy (12-week-old)[1]
Dosage: 2.5 mg/d
Administration: Subcutaneous implantation; 42 days; treated with 2 mg Tamoxifen (HY-13757A) (20 mg/mL in sunflower oil and 10% ethanol; i.p.; once daily on 5 consecutive days) at least 4 weeks before nephrectomy
Result: Increased the blood pressure without differences between both genotypes (MRCdh5Cre and MRwild-type).
Resulted glomerular injury and proteinuria, renal inflammation and fibrosis.
Molecular Weight

372.50

Formula

C23H32O4

CAS No.
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@@H](C(COC(C)=O)=O)CC[C@@]1([H])[C@]3([H])CCC4=CC(CC[C@]4(C)[C@@]3([H])CC2)=O

Structure Classification
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 1 year
-20°C 6 months
Solvent & Solubility
In Vitro: 

DMSO : 41.67 mg/mL (111.87 mM; ultrasonic and warming and heat to 80°C)

H2O : 1 mg/mL (2.68 mM; ultrasonic and warming and heat to 80°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6846 mL 13.4228 mL 26.8456 mL
5 mM 0.5369 mL 2.6846 mL 5.3691 mL
10 mM 0.2685 mL 1.3423 mL 2.6846 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (5.58 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.08 mg/mL (5.58 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.67 mg/mL (4.48 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 99.57%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Deoxycorticosterone acetate
Cat. No.:
HY-B1472
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