RAC3 Antibody (YA1802)(PBS only)

Cat. No.: HY-P82057A: Data Sheet User Guide for Antibodies
FAQs
Technical Support

RAC3 Antibody (YA1802) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAC3.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

* Please select Quantity before adding items.

WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

RAC3 Antibody (YA1802) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RAC3.

Host

Rabbit

Molecular Weight

Predicted band size: 21 kDa;

Observed band size: 21 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human, Mouse, Rat

SwissProt ID

P60763

Gene ID

5881 [NCBI]

Immunogen

A synthetic peptide of human RAC3 aa122-135.

Application &
Dilution Ratio

Application	Dilution Ratio
WB WB: Western Blot	1:500-1:1000
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:50-1:100

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles. Promotes cell adhesion and spreading on fibrinogen in a CIB1 and alpha-IIb/beta3 integrin-mediated manner

Subcellular Localization：Cytoplasm; Endomembrane system; Cell projection, lamellipodium; Cytoplasm, perinuclear region; Cell membrane; Cytoplasm, cytoskeleton

Expression：
Tissue_specificity:Highest levels in brain, also detected in heart, placenta and pancreas.

Induction:Expression down-regulated in quiescent fibroblasts and clearly induced by serum stimulation

Subunit：Interacts with the GEF protein DOCK7, which promotes the exchange between GDP and GTP, and therefore activates it (PubMed:16982419). Interacts with C1D (PubMed:9852280). Interacts (via C-terminal region) with CIB1; the interaction induces their association with the cytoskeleton upon alpha-IIb/beta3 integrin-mediated adhesion (PubMed:11756406). Interacts with NRBP (PubMed:11956649)

Research Field

Signal Transduction

Synonyms

ras-related C3 botulinum toxin substrate 3 (rho family; small GTP binding protein Rac3)

Documentation

User Guide for Antibodies (1077 KB)