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Cat. No.: HY-187569

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(Rac)-3-OH-Simvastatin

(Rac)-3-OH-Simvastatin is a metabolite of Simvastatin (HY-17502). Simvastatin is an orally active competitive inhibitor of HMG-CoA reductase (HMGCR) with a K_i of 0.2 nM.

For research use only. We do not sell to patients.

CAS No.: 134523-09-4
Formula: C₂₅H₃₈O₆
Molecular Weight:434.57

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

(Rac)-3-OH-Simvastatin Chemical Structure

CAS No.: 134523-09-4

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

(Rac)-3-OH-Simvastatin is a metabolite of Simvastatin (HY-17502). Simvastatin is an orally active competitive inhibitor of HMG-CoA reductase (HMGCR) with a K_i of 0.2 nM^[1].

Chemical Information

CAS No. 134523-09-4
Molecular Weight 434.57
Formula C₂₅H₃₈O₆
SMILES

O=C1OC(CC(C1)O)CCC2C(C)C=CC3=CC(C)(CC(C32)OC(C(C)(CC)C)=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Vickers S, et al. In vitro and in vivo biotransformation of simvastatin, an inhibitor of HMG CoA reductase. Drug Metab Dispos. 1990 Jul-Aug;18(4):476-83. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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