RHOQ - ras homolog family member Q Gene

Also Known as ARHQ; TC10; TC10A; RASL7A; HEL-S-42

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 23433

About RHOQ

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:46,542,490-46,584,688 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues and 22 paralogues. Ubiquitous expression in fat (RPKM 72.1), heart (RPKM 55.0) and 24 other tissues.

Summary

This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin Cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein is an important signalling protein for sarcomere assembly and has been shown to play a significant role in the exocytosis of the solute carrier family 2, facilitated glucose transporter member 4 and Other proteins, possibly acting as the signal that turns on the membrane fusion machinery. Three related pseudogene have been identified on chromosomes 2 and 14. [provided by RefSeq, Aug 2011]

RHOQ Products (1)

mRNA	Protein	Name
NM_012249.4	NP_036381.2	rho-related GTP-binding protein RhoQ

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables GBD domain binding	IPI IPI: Inferred from physical interaction	10445846	GOA
enables GTPase activity	IDA IDA: Inferred from direct assay	10445846	GOA
enables profilin binding	IPI IPI: Inferred from physical interaction	10445846	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in GTP metabolic process	IDA IDA: Inferred from direct assay	10445846	GOA
involved in cellular response to insulin stimulus	IMP IMP: Inferred from mutant phenotype	11309621	GOA
involved in cortical actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	11821390	GOA
involved in insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11309621	GOA
involved in negative regulation of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	11309621	GOA
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	11309621	GOA
involved in positive regulation of filopodium assembly	IDA IDA: Inferred from direct assay	10445846	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	10445846	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in actin filament	IDA IDA: Inferred from direct assay	10445846	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	10445846	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RHOQ Protein Structure

Ras

0
100
205 a.a.

Protein Preferred Names	Protein Names
rho-related GTP-binding protein RhoQ	RAS-like, family 7, member A

RHOQ Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RHOQ	P17081	MORN4	Homo sapiens	Q8NDC4	Validated Y2H	32296183
Intra	RHOQ	P17081	BANP	Homo sapiens	Q8N9N5-2	Validated Y2H	32296183
Intra	RHOQ	P17081	PARD6B	Homo sapiens	Q9BYG5	Validated Y2H	32296183
Intra	RHOQ	P17081	ZNF417	Homo sapiens	Q8TAU3	Validated Y2H	32296183
Intra	RHOQ	P17081	NTAQ1	Homo sapiens	Q96HA8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

RHOQ Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82437	RHOQ Antibody (YA2182)	WB, ICC/IF	Human, Rat

Related Diseases

Diseases	Alias
Clostridium Difficile Colitis	Pseudomembranous Colitis Colitis Pseudomembranous Enterocolitis, Pseudomembranous Pseudomembranous Enterocolitis Clostridium Difficile Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11956	RHOQ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RHOQ	MGD	MGI:1931553
Bos taurus	RHOQ	VGNC	VGNC:33952
Macaca mulatta	RHOQ	VGNC	VGNC:76754
Rattus norvegicus	RHOQ	RGD	RGD:621626
Canis familiaris	RHOQ	VGNC	VGNC:54538
Felis catus	RHOQ	VGNC	VGNC:81208
Others	RHOQ	NCBI