Mcl-1 inhibitor 20
Mcl-1 inhibitor 20 (compound 47) is a Mcl-1 inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity.
For research use only. We do not sell to patients.
- Formula: C55H61ClFN5O7S
- Molecular Weight:990.62
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Ki: 24 nM (Mcl-1 BH3)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| H9c2 | IC50 |
17.94 μM
Compound: 47
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Cytotoxicity against rat H9c2 cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against rat H9c2 cells assessed as cell viability measured after 72 hrs by MTT assay
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[PMID: 39121336] |
| HL-60 | IC50 |
5.2 μM
Compound: 47
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Antiproliferative activity against human HL-60 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
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[PMID: 39121336] |
| MOLM-13 | IC50 |
8.52 μM
Compound: 47
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Antiproliferative activity against human MOLM-13 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human MOLM-13 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
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[PMID: 39121336] |
| THP-1 | IC50 |
8.83 μM
Compound: 47
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Antiproliferative activity against human THP-1 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human THP-1 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
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[PMID: 39121336] |
| U-937 | IC50 |
8.33 μM
Compound: 47
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Antiproliferative activity against human U-937 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human U-937 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
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[PMID: 39121336] |
Chemical Information
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Molecular Weight 990.62
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Formula C55H61ClFN5O7S
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SMILES
O=C(C(N1CCN2CCOCC2)=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=C1C(C5=CC=CC=C5CN6C=C(CCN(CCN7CCOCC7)S(C8=CC=C(F)C=C8)(=O)=O)C9=C6C=CC=C9)=CC=C4)O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Mcl-1 inhibitor 20 Related Classifications
HY-159588 Related Classifications
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