2. Apoptosis
  3. Bcl-2 Family
  4. Mcl-1 inhibitor 20

Mcl-1 inhibitor 20 (compound 47) is a Mcl-1 inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity.

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Mcl-1 inhibitor 20

Mcl-1 inhibitor 20 Chemical Structure

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Mcl-1 inhibitor 20 Related Antibodies

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Description

Mcl-1 inhibitor 20 (compound 47) is a Mcl-1 inhibitor with anti-leukemic effects. Mcl-1 inhibitor 20 can bind to the BH3 binding groove of Mcl-1 (Ki=24 nM), occupy the P1 pocket in Mcl-1, and form interactions with Lys234 and Val249. Mcl-1 inhibitor 20 has good microsomal stability, pharmacokinetic characteristics and low cardiotoxicity[1].

IC50 & Target

Ki: 24 nM (Mcl-1 BH3)[1]
Cellular Effect
Cell Line Type Value Description References
H9c2 IC50
17.94 μM
Compound: 47
Cytotoxicity against rat H9c2 cells assessed as cell viability measured after 72 hrs by MTT assay
Cytotoxicity against rat H9c2 cells assessed as cell viability measured after 72 hrs by MTT assay
[PMID: 39121336]
HL-60 IC50
5.2 μM
Compound: 47
Antiproliferative activity against human HL-60 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human HL-60 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
[PMID: 39121336]
MOLM-13 IC50
8.52 μM
Compound: 47
Antiproliferative activity against human MOLM-13 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human MOLM-13 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
[PMID: 39121336]
THP-1 IC50
8.83 μM
Compound: 47
Antiproliferative activity against human THP-1 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human THP-1 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
[PMID: 39121336]
U-937 IC50
8.33 μM
Compound: 47
Antiproliferative activity against human U-937 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
Antiproliferative activity against human U-937 cells assessed as growth inhibition measured after 72 hrs by CCK-8 assay
[PMID: 39121336]
Molecular Weight

990.62

Formula

C55H61ClFN5O7S
SMILES

O=C(C(N1CCN2CCOCC2)=C(CCCOC3=CC(C)=C(Cl)C(C)=C3)C4=C1C(C5=CC=CC=C5CN6C=C(CCN(CCN7CCOCC7)S(C8=CC=C(F)C=C8)(=O)=O)C9=C6C=CC=C9)=CC=C4)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Mcl-1 inhibitor 20 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mcl-1 inhibitor 20Bcl-2 FamilyInhibitorinhibitorinhibit

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