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Cat. No.: HY-153423

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Mcl-1 inhibitor 12

Mcl-1 inhibitor 12 (Example 10) is a MCL-1 inhibitor (K_i: 0.22 nM). Mcl-1 inhibitor 12 can be used for the research of cancers.

For research use only. We do not sell to patients.

CAS No.: 2445466-24-8
Formula: C₄₇H₄₅ClFN₇O₆
Molecular Weight:858.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Mcl-1 inhibitor 12 Chemical Structure

CAS No.: 2445466-24-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Mcl-1 inhibitor 12 (Example 10) is a MCL-1 inhibitor (K_i: 0.22 nM). Mcl-1 inhibitor 12 can be used for the research of cancers^[1].

IC₅₀ & Target^[1]

Mcl-1

0.22 nM (Ki)

All Bcl-2 Family Isoforms :

Chemical Information

CAS No. 2445466-24-8
Molecular Weight 858.35
Formula C₄₇H₄₅ClFN₇O₆
SMILES

COC1=CC=CC=C1C2=NC(COC3=C(C[C@H](C(O)=O)OC4=NC=NN5C4=[C@]([C@]6=C(C)C(Cl)=C(OCCN7CCN(C)CC7)C=C6)C(C8=CC=C(F)C=C8)=C5)C=CC=C3)=CC=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Jincong Zhuo, et al. 2-((5-(phenyl)-pyrrolo[2,1-f][1,2,4]triazin-4-yl)amino)-3-(phenyl)propanoic acid derivatives and related compounds as mcl-1 enzyme inhibitors for treating cancer. Patent WO2020123994.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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Mcl-1 inhibitor 12

All Bcl-2 Family Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Mcl-1 inhibitor 12 Related Classifications

HY-153423 Related Classifications