SPON1 - spondin 1 Gene

Homo sapiens

Also known as f-spondin; VSGP/F-spondin

Gene ID: 10418 | Gene type: protein coding

About SPON1

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:13,962,723-14,268,133 (from NCBI)

This gene has 2 transcripts (splice variants), 287 orthologues and 3 paralogues. Broad expression in gall bladder (RPKM 73.6), urinary bladder (RPKM 33.9) and 16 other tissues.

Summary

Predicted to be an extracellular matrix structural constituent. Predicted to be involved in cell adhesion. Predicted to act upstream of or within positive regulation of protein binding activity; positive regulation of protein processing; and regulation of amyloid precursor protein catabolic process. Located in extracellular space. Colocalizes with collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

SPON1 Products(1)

mRNA	Protein	Name
NM_006108.4	NP_006099.2	spondin-1 precursor

SPON1 Protein Structure

Reeler

Spond_N

TSP_1

0
200
400
600
807 a.a.

Protein Preferred Names

Protein Names

spondin-1

spondin 1, (f-spondin) extracellular matrix protein

Related Diseases

Diseases

Alias

Peters-Plus Syndrome

Krause-Kivlin Syndrome	Peters Plus Syndrome
Peters Anomaly	Irido-Corneo-Trabecular Dysgenesis
PTRPLS	Peters Anomaly With Short-Limb Dwarfism
Peters Anomaly-Short Limb Dwarfism Syndrome	Peters Anomaly With Short Limb Dwarfism
Peters Congenital Glaucoma	Krause-Van Schooneveld-Kivlin Syndrome
Peters' Plus Syndrome	Peters'-Plus Syndrome
Anomaly Peters

Coffin-Siris Syndrome 1

Coffin-Siris Syndrome	Fifth Digit Syndrome
Css	CSS1
Mrd12	Mental Retardation, Autosomal Dominant 12
Hhid	Dwarfism-Onychodysplasia
Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features	Autosomal Dominant Mental Retardation 12
Short Stature-Onychodysplasia.	Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx
Mental Retardation With Hypoplastic Fifth Fingernails And Toenails	Short Stature-Onychodysplasia
Coffin-Siris Syndrome, Type 1	Mental Retardation, Autosomal Dominant, Type 12

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13698	SPON1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SPON1	VGNC	VGNC:104331
Bos taurus	SPON1	VGNC	VGNC:35227
Canis familiaris	SPON1	VGNC	VGNC:46752
Rattus norvegicus	SPON1	RGD	RGD:619918
Macaca mulatta	SPON1	VGNC	VGNC:77862
Mus musculus	SPON1	MGD	MGI:2385287

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