HTR1B - 5-hydroxytryptamine receptor 1B Gene

Also Known as S12; 5-HT1B; HTR1D2; HTR1DB; 5-HT-1B; 5-HT1DB; 5-HT-1D-beta

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3351

About HTR1B

Cytogenetic location: 6q14.1 Genomic coordinates (GRCh38): 6:77,460,924-77,463,491 (from NCBI)

This gene has 1 transcript (splice variant), 246 orthologues and 8 paralogues.

Summary

The protein encoded by this intronless gene is a G-protein coupled receptor for serotonin (5-hydroxytryptamine). Ligand binding activates second messengers that inhibit the activity of Adenylate Cyclase and manage the release of serotonin, dopamine, and acetylcholine in the brain. The encoded protein may be involved in several neuropsychiatric disorders and therefore is often a target of antidepressant and Other psychotherapeutic drugs. [provided by RefSeq, Nov 2015]

HTR1B Products (1)

mRNA	Protein	Name
NM_000863.3	NP_000854.1	5-hydroxytryptamine receptor 1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables G protein-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	1315531	GOA
enables Gi/o-coupled serotonin receptor activity	IDA IDA: Inferred from direct assay	1348246	GOA
enables Gi/o-coupled serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	29925951	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24722188	GOA
enables serotonin receptor activity	IMP IMP: Inferred from mutant phenotype	29925951	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	8882600	GOA
involved in adenylate cyclase-inhibiting serotonin receptor signaling pathway	IDA IDA: Inferred from direct assay	1315531	GOA
involved in cellular response to alkaloid	IDA IDA: Inferred from direct assay	1315531	GOA
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	1315531	GOA
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	25871906	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	1652050	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	1315531	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HTR1B Protein Structure

7tm_1

0
100
200
300
390 a.a.

Protein Preferred Names	Protein Names
5-hydroxytryptamine receptor 1B	5-hydroxytryptamine (serotonin) receptor 1B, G protein-coupled

HTR1B Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Verweise
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Array	25416956
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Bait-Prey Pool	25910212
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Validated Y2H	25910212
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Array	24722188
Intra	HTR1B	P28222	MDFI	Homo sapiens	Q99750	Y2H Array	25910212
Intra	HTR1B	P28222	ACTN2	Homo sapiens	P35609	Validated Y2H	32296183
Intra	HTR1B	P28222	ACTN2	Homo sapiens	P35609	Y2H Array	32296183
Intra	HTR1B	P28222	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Obsessive-Compulsive Disorder	OCD Obsessive-Compulsive Disorder, Susceptibility To Anancastic Neurosis Obsessive Compulsive Disorder Anankastic Neurosis Obsessive-Compulsive Neurosis Obsessive Compulsive Behavior
Personality Disorder	Personality Disorders Character Disorder Personality Specific Personality Disorders Enduring Personality Change After Psychiatric Illness
Bulimia Nervosa	Bulimia Bulimia Nervosa, Susceptibility To Binge Eating Disorder BULN Bn Hyperorexia Nervosa Bulimia Nervosa 2 BULN2 Susceptibility To Bulimia Nervosa Bulimia Nervosa, Susceptibility To, Type 2 Bn - [Bulimia Nervosa] Bulimia Nos Bulimic Bingeing Binge Overeating Bouts Of Overeating Episodes Of Overeating
Mood Disorder	Mood Disorders Episodic Mood Disorder
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Migraine With Aura	Classic Migraine Migraine With Typical Aura Migraine Accompagnée Complicated Migraine Classical Migraine Acute Migraine With Aura
Alcohol Dependence	Alcoholism Alcohol Dependence, Susceptibility To Alcohol Dependence, Protection Against Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against Alcoholism, Susceptibility To Alcoholic Intoxication, Chronic Pharyngeal Neoplasms Chronic Alcoholism Dipsomania Alcohol Addiction Ethanol Dependence Chronic Ethanolism Chronic Alcoholic Disease Nos Alcoholic Disease Nos Alcoholic
Borderline Personality Disorder
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Acute Frontal Sinusitis
Antisocial Personality Disorder	Dissocial Personality Disorder Asocial Personality Psychopath.Personality Psychopathic Personality Psychopathic Personality Disorder Sociopathic Personality
Pulmonary Hypertension	Primary Pulmonary Hypertension Hypertension Pulmonary Hypertension, Pulmonary Hypertension, Pulmonary, Primary Idiopathic Pulmonary Hypertension Idiopathic Pulmonary Arterial Hypertension Pulmonary Htn - [Hypertension]
Panic Disorder	Panic Anxiety Syndrome Panic Panic Disorder 1 Episodic Paroxysmal Anxiety Disorder
Mesenteric Vascular Occlusion
Psychosexual Disorder	Psychosexual Disorders
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Narcolepsy	Paroxysmal Sleep Gelineau Syndrome Narcoleptic Syndrome Narcolepsy-Cataplexy Syndrome Cataplexy And Narcolepsy Narcolepsy, Without Cataplexy Gelineau'S Syndrome Narcolepsy With Or Without Cataplexy Narcolepsy Nos
Amphetamine Abuse
Sexual Health Disorder	Sexual Health
Pyromania	Firesetting Behavior Pathological Firesetting Pathological Fire-Setting
Inhibited Male Orgasm	Male Orgasmic Disorder Psychosexual Dysfunction With Male Orgasmic Disorder
Oppositional Defiant Disorder	Disorder Oppositional Defiance Behavioural Disorder Oppositional Defiance Disruptive Mood Dysregulation Disorder
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Mental Depression	Depression Depressive Disorder
Generalized Anxiety Disorder	Anxiety Generalized
Motion Sickness	Airsickness Carsickness Seasickness Travel Sickness Riders' Vertigo
Vascular Disease	Vascular Diseases Aneurysm Spinal Cord Ischemia Vascular Anomaly Spinal Cord Vascular Diseases Vascular Tissue Disease
Substance Dependence
Nervous System Disease	Abnormality Of The Nervous System Nervous System Diseases Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS06461	HTR1B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20424	Htr1b Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26933	Htr1b Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	HTR1B	VGNC	VGNC:73537
Rattus norvegicus	HTR1B	RGD	RGD:2846
Felis catus	HTR1B	VGNC	VGNC:67668
Mus musculus	HTR1B	MGD	MGI:96274
Bos taurus	HTR1B	VGNC	VGNC:29992
Others	HTR1B	NCBI