TNP2 - transition protein 2 Gene

Also Known as TP2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7142

About TNP2

Cytogenetic location: 16p13.13 Genomic coordinates (GRCh38): 16:11,267,857-11,269,325 (from NCBI)

This gene has 2 transcripts (splice variants) and 66 orthologues. Restricted expression toward testis (RPKM 12.9).

Summary

Predicted to enable zinc ion binding activity. Predicted to be involved in positive regulation of protein processing; single fertilization; and spermatogenesis, exchange of chromosomal proteins. Predicted to act upstream of or within binding activity of sperm to zona pellucida and flagellated sperm motility. Predicted to be located in nucleus. Predicted to be part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]

TNP2 Products (1)

mRNA Protein Name
NM_005425.5 NP_005416.1 nuclear transition protein 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
31515488 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNP2 Protein Structure

TP2

TP2: Nuclear transition protein 2 (1 - 138)

  • 0
  • 100
  • 138 a.a.
Protein Preferred Names Protein Names

nuclear transition protein 2

  • TP-2

TNP2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TNP2 Q05952 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
TNP2 Q05952 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
TNP2 Q05952 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
32296183
Intra
TNP2 Q05952 KRTAP10-9 Homo sapiens P60411
Y2H Array
32296183
Intra
TNP2 Q05952 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
TNP2 Q05952 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
TNP2 Q05952 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
TNP2 Q05952 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
TNP2 Q05952 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
TNP2 Q05952 KRTAP2-4 Homo sapiens Q9BYR9
Validated Y2H
32296183
Intra
TNP2 Q05952 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Array
32296183
Intra
TNP2 Q05952 KRTAP2-4 Homo sapiens Q9BYR9
Y2H Prey Pooling
32296183
Intra
TNP2 Q05952 MDFI Homo sapiens Q99750
Validated Y2H
32296183
Intra
TNP2 Q05952 MDFI Homo sapiens Q99750
Y2H Array
32296183
Intra
TNP2 Q05952 MDFI Homo sapiens Q99750
Y2H Prey Pooling
32296183
Intra
TNP2 Q05952 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
32296183
Intra
TNP2 Q05952 APPBP2 Homo sapiens Q92624
Y2H Array
32296183
Intra
TNP2 Q05952 APPBP2 Homo sapiens Q92624
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Male Infertility

  • Infertility, Male

  • Infertility Male

  • Male Sterility

  • Absolute Infertility
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Epididymo-Orchitis
Infertility
Oligoasthenoteratozoospermia

  • Oat

  • Oligoasthenoteratospermia
Embryonal Testis Carcinoma

  • Testicular Embryonal Carcinoma

  • Embryonal Carcinoma Of Testis

  • Embryonal Carcinoma Of The Testis
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Oligospermia
Cryptorchidism, Unilateral Or Bilateral

  • Cryptorchidism

  • Undescended Testicle

  • Undescended Testis

  • Cryptorchism

  • Undescended Testicles

  • CRYPTO

  • Impaired Testicular Descent

  • Cryptosporidiosis

  • Retained Testis

  • Unilateral Cryptorchidism

  • Unilateral Undescended Testis

  • Nondescent Unilateral Testicle

  • Unilateral Cryptorchism

  • Ectopic Testis, Unilateral

  • Bilateral Cryptorchidism

  • Bilateral Cryptorchism

  • Bilateral Nondescent Testicle

  • Bilateral Undescended Testes

  • Bilateral Ectopic Testes
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14858 TNP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNP2 RGD RGD:3885
Mus musculus TNP2 MGD MGI:98785
Bos taurus TNP2 VGNC VGNC:36198
Felis catus TNP2 VGNC VGNC:66430
Macaca mulatta TNP2 VGNC VGNC:78608
Canis familiaris TNP2 VGNC VGNC:82301
Others TNP2 NCBI