PHLDA1 - pleckstrin homology like domain family A member 1 Gene

Also Known as PHRIP; TDAG51; DT1P1B11

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22822

About PHLDA1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:76,025,447-76,031,776 (from NCBI)

This gene has 3 transcripts (splice variants), 172 orthologues and 2 paralogues. Ubiquitous expression in salivary gland (RPKM 37.9), liver (RPKM 29.7) and 25 other tissues.

Summary

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]

PHLDA1 Products (1)

mRNA Protein Name
NM_007350.3 NP_031376.3 pleckstrin homology-like domain family A member 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11369516 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pleckstrin homology-like domain family A member 1

  • PQ-rich protein

PHLDA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PHLDA1 Q8WV24 EIF3D Homo sapiens O15371
Y2H
11369516
Intra
PHLDA1 Q8WV24 EIF3D Homo sapiens O15371
Pull Down
11369516
Intra
PHLDA1 Q8WV24 PABPC4 Homo sapiens Q13310
Pull Down
11369516
Intra
PHLDA1 Q8WV24 MDFI Homo sapiens Q99750
Y2H Array
19060904
Intra
PHLDA1 Q8WV24 MDFI Homo sapiens Q99750
Y2H Pooling
19060904
Cross: Cross-species interaction Intra: Intraspecies interaction

PHLDA1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81871 PHLDA1 Antibody (YA1616) WB, IHC-F, IHC-P, ICC/IF Human
HY-P81871A PHLDA1 Antibody (YA1616)(PBS only) WB, IHC-F, IHC-P, ICC/IF Human

Related Diseases

Diseases Alias
Malignant Syringoma

  • Microcystic Adnexal Carcinoma

  • Microcystic Adnexal Carcinoma Of Skin

  • Syringomatous Carcinoma

  • Eccrine Epithelioma
Fibroepithelial Basal Cell Carcinoma

  • Fibroepithelioma Of Pinkus

  • Fibroepithelioma Of Pinkus Type

  • Pinkus Tumor
Inverted Follicular Keratosis

  • Inverted Folicular Keratosis

  • Seborrheic Keratosis
Malignant Acrospiroma

  • Eccrine Ductal Carcinoma

  • Hidradenocarcinoma

  • Anaplastic Syringoma

  • Eccrine Ductal Carcinoma Of Skin

  • Clear Cell Eccrine Carcinoma

  • Malignant Clear Cell Acrospiroma

  • Malignant Nodular/Clear Cell Hidradenoma

  • Primary Mucoepidermoid Cutaneous Carcinoma

  • Sweat Gland Adenocarcinoma
Follicular Infundibulum Tumor

  • Tumor Of Follicular Infundibulum

  • Follicular Infundibulum Tumour

  • Neoplasm Of The Follicular Infundibulum

  • Tumour Of Follicular Infundibulum
Morpheaform Basal Cell Carcinoma

  • Basal Cell Carcinoma, Morphea

  • Cicatricial Basal-Cell Carcinoma

  • Morphea-Type Basal Cell Carcinoma

  • Morpheic Basal Cell Carcinoma
Clear Cell Basal Cell Carcinoma

  • Skin Clear Cell Basal Cell Carcinoma
Basal Cell Carcinoma, Infundibulocystic

  • Basal Cell Carcinoma With Follicular Differentiation

  • Infundibulocystic Basal Cell Carcinoma

  • Skin Infundibulocystic Basal Cell Carcinoma
Pilar Sheath Acanthoma

  • Acanthoma, Pilar Sheath
Aggressive Digital Papillary Adenocarcinoma
Epidermal Appendage Tumor

  • Neoplasm Of Skin With Adnexal Differentiation

  • Neoplasm Of The Skin Appendage

  • Skin Appendage Tumour
Squamous Papillomatosis
Eccrine Sweat Gland Cancer

  • Malignant Eccrine Skin Neoplasm

  • Malignant Eccrine Tumor
Sweat Gland Cancer

  • Sweat Gland Carcinoma

  • Malignant Neoplasm Of Sweat Gland

  • Malignant Tumor Of The Sweat Gland

  • Carcinoma Of The Sweat Gland

  • Primary Malignant Neoplasm Of Sweat Gland

  • Sweat Gland Neoplasms
Hair Follicle Neoplasm

  • Hair Matrix Neoplasm

  • Hair Matrix Tumour
Syringocystadenoma Papilliferum

  • Fistulous Vegetative Verrucous Hydradenoma

  • Papillary Syringadenoma

  • Naevus Syringocystadenomatosus Papilliferus

  • Papillary Syringocystadenoma

  • Scap

  • Syringadenoma Papilliferum

  • Papillary Hidradenoma
Acanthoma
Hidrocystoma

  • Apocrine Cystadenoma

  • Eccrine Hidrocystoma

  • Eccrine Cystadenoma

  • Eccrine Hidrocystoma Of Skin

  • Apocrine Adenoma
Brooke-Spiegler Syndrome

  • Cyld Cutaneous Syndrome

  • Spiegler-Brooke Syndrome

  • Familial Cylindromatosis

  • BRSS

  • Bss

  • Sbs

  • Multiple Familial Trichoepithelioma

  • Ancell-Spiegler Cylindromas

  • Familial Multiple Trichoepithelioma

  • Trichoepithelioma

  • Fc

  • Mft

  • Multiple Familial Trichoepitheliomas

  • Ccs

  • Turban Tumor Syndrome

  • Schilbach-Rott Syndrome

  • Eccrine Dermal Cylindroma

  • Familial Multiple Trichoepitheliomata
Hidradenoma

  • Adenoma, Sweat Gland

  • Hidradenoma Of Skin

  • Sweat Gland Adenoma

  • Syringoadenoma

  • Eccrine Acrospiroma

  • Benign Neoplasm Of Sweat Gland
Eccrine Papillary Adenocarcinoma

  • Digital Papillary Adenocarcinoma

  • Sweat Gland Adenocarcinoma

  • Digital Papillary Eccrine Carcinoma Of Skin
Basosquamous Carcinoma

  • Carcinoma, Basosquamous

  • Basisquamous Cell Carcinoma

  • Basosquamous Cell Carcinoma

  • Metatypical Carcinoma
Pilomatrixoma

  • Pilomatricoma

  • PTR

  • Epithelioma Calcificans Of Malherbe

  • Benign Pilomatricoma

  • Calcifying Epithelioma Of Malherbe

  • Pilomatricoma, Somatic

  • Benign Pilomatrixoma

  • Malherbe Calcifying Epithelioma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10442 PHLDA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19520 Phlda1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26015 Phlda1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PHLDA1 VGNC VGNC:68830
Rattus norvegicus PHLDA1 RGD RGD:3836
Mus musculus PHLDA1 MGD MGI:1096880
Bos taurus PHLDA1 VGNC VGNC:32835
Canis familiaris PHLDA1 VGNC VGNC:44501
Others PHLDA1 NCBI