WNT11 - Wnt family member 11 Gene

Also Known as HWNT11

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7481

About WNT11

Cytogenetic location: 11q13.5 Genomic coordinates (GRCh38): 11:76,186,325-76,210,761 (from NCBI)

This gene has 3 transcripts (splice variants), 224 orthologues and 18 paralogues. Broad expression in fat (RPKM 7.4), adrenal (RPKM 3.7) and 15 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family. It encodes a protein which shows 97%, 85%, and 63% amino acid identity with mouse, chicken, and Xenopus Wnt11 protein, respectively. This gene may play roles in the development of skeleton, kidney and lung, and is considered to be a plausible candidate gene for High Bone Mass Syndrome. [provided by RefSeq, Jul 2008]

WNT11 Products (1)

mRNA	Protein	Name
NM_004626.3	NP_004617.2	protein Wnt-11 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables protein kinase activator activity	IMP IMP: Inferred from mutant phenotype	20219091	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	9757009	GOA
involved in cloacal septation	IEP IEP: Inferred from expression pattern	9757009	GOA
involved in embryonic skeletal system development	IEP IEP: Inferred from expression pattern	9757009	GOA
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	20103596	GOA
involved in lung-associated mesenchyme development	IEP IEP: Inferred from expression pattern	9757009	GOA
involved in mesonephric duct development	IEP IEP: Inferred from expression pattern	9757009	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	20103596	GOA
involved in neuroendocrine cell differentiation	IMP IMP: Inferred from mutant phenotype	20219091	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	19847889	GOA
involved in secondary palate development	IMP IMP: Inferred from mutant phenotype	18413325	GOA
involved in signal transduction	IMP IMP: Inferred from mutant phenotype	20219091	GOA
involved in ureteric bud morphogenesis	IEP IEP: Inferred from expression pattern	9757009	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	20103596	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT11 Protein Structure

wnt

0
100
200
300
354 a.a.

Protein Preferred Names	Protein Names
protein Wnt-11	wingless-type MMTV integration site family, member 11

WNT11 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WNT11	O96014	KRTAP10-8	Homo sapiens	P60410	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP10-9	Homo sapiens	P60411	Validated Y2H	25416956
Intra	WNT11	O96014	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	WNT11	O96014	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP9-3	Homo sapiens	Q9BYQ3	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP9-3	Homo sapiens	Q9BYQ3	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP1-5	Homo sapiens	Q9BYS1	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP1-5	Homo sapiens	Q9BYS1	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP1-3	Homo sapiens	Q8IUG1	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP12-3	Homo sapiens	P60328	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP1-1	Homo sapiens	Q07627	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP5-7	Homo sapiens	Q6L8G8	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP5-7	Homo sapiens	Q6L8G8	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP17-1	Homo sapiens	Q9BYP8	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP17-1	Homo sapiens	Q9BYP8	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP5-8	Homo sapiens	O75690	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP5-8	Homo sapiens	O75690	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	WNT11	O96014	KRTAP5-9	Homo sapiens	P26371	Validated Y2H	32296183
Intra	WNT11	O96014	KRTAP5-9	Homo sapiens	P26371	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	KRTAP5-9	Homo sapiens	P26371	Y2H Array	32296183
Intra	WNT11	O96014	RASSF10	Homo sapiens	A6NK89	Y2H Array	32296183
Intra	WNT11	O96014	RASSF10	Homo sapiens	A6NK89	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	WNT11	O96014	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	WNT11	O96014	MDFI	Homo sapiens	Q99750	Y2H Array	30886144
Intra	WNT11	O96014	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	WNT11	O96014	CCNDBP1	Homo sapiens	O95273	Y2H Prey Pooling	32296183
Intra	WNT11	O96014	CCNDBP1	Homo sapiens	O95273	Y2H Array	32296183
Intra	WNT11	O96014	FUCA2	Homo sapiens	Q9BTY2	Y2H Array	32296183
Intra	WNT11	O96014	FUCA2	Homo sapiens	Q9BTY2	Validated Y2H	32296183
Intra	WNT11	O96014	FUCA2	Homo sapiens	Q9BTY2	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Renal Hypoplasia
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Renal Hypodysplasia/Aplasia 1	Renal Agenesis Renal Adysplasia Renal Aplasia RHDA1 Hereditary Renal Aplasia Hra Hereditary Urogenital Adysplasia Hypodysplasia/Aplasia, Renal, Type 1 Congenital Absence Of Kidneys Syndrome Congenital Absence Of Kidney Aplastic Kidney
Fallopian Tube Serous Adenocarcinoma
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Neural Tube Defects	Spina Bifida Neural Tube Defect NTD Neural Tube Defects, Susceptibility To Spinal Dysraphism Spina Bifida, Susceptibility To Rachischisis Cleft Spine Open Spine Hydrocele Spinalis Neural Tube Defect Nos Sb - [Spina Bifida] Spinal Hernia Nos Spinal Fissure Nos
Double Outlet Right Ventricle	Double Outlet Right Ventricle With Subpulmonary Ventricular Septal Defect Taussig-Bing Syndrome Dextrotransposition Of Aorta Taussig-Bing Syndrome Or Defect Dorv Dorv With Subpulmonary Vsd Dorv-Tga Double Outlet Right Ventricle With Transposition Of The Great Arteries Double Outlet Right Ventricle With Subpulmonary Interventricular Communication, Transposition Type Taussig-Bing Heart Taussig-Bing Malformation Taussig-Bing Complex Taussig-Bing Defect Taussig-Bing Double Outlet Right Ventricle With Remote Ventricular Septal Defect Double Outlet Right Ventricle With Uncommitted Ventricular Septal Defect Double Outlet Right Ventricle With Non-Committed Interventricular Communication Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication Without Pulmonary Stenosis Double Outlet Right Ventricle With Subaortic Or Doubly Committed Interventricular Communication And Pulmonary Stenosis
Cleft Palate, Isolated	Cleft Palate Isolated Cleft Palate CPI Cp Palatoschisis Cleft Palate Isolated Uranostaphyloschisis Congenital Fissure Of Palate Cleft Of Secondary Palate
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Strabismus	Strabismus, Susceptibility To Strabismus, Susceptibility To, 1 Strabismus 1
Orofacial Cleft	Cleft, Orofacial
Tooth Agenesis	Oligodontia Hypodontia Selective Tooth Agenesis Tooth Agenesis, Selective Familial Tooth Agenesis Anodontia Congenital Absence Of One Tooth
Tetralogy Of Fallot	TOF Fallot Tetralogy Ventricular Septal Defect With Pulmonary Stenosis Or Atresia, Dextraposition Of Aorta, And Hypertrophy Of Right Ventricle Tetrad Of Fallot Fallot Tetrad Fallot Disease Fallot Complex Subpulmonic Stenosis, Ventricular Septal Defect, Overriding Aorta, And Right Ventricular Hypertrophy Interventricular Septal Defect With Dextroposition Of Aorta, Pulmonary Stenosis And Hypertrophy Of Right Ventricle Interventricular Septal Defect, In Tetralogy Of Fallot Ventricular Septal Defect With Obstructed Right Ventricular Outflow Tof - [Tetralogy Of Fallot] Pulmonary Atresia With Ventricular Septal Defect [Fallot Type] Pulmonary Atresia, Ventricular Septal Defect And Mapcas Pulmonary Atresia With Ventricular Septal Defect And Systemic-To-Pulmonary Collateral Arteries [Fallot Type]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0899	Wilforine	Inhibitor	99.47%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WNT11	VGNC	VGNC:78795
Mus musculus	WNT11	MGD	MGI:101948
Bos taurus	WNT11	VGNC	VGNC:36955
Canis familiaris	WNT11	VGNC	VGNC:48421
Rattus norvegicus	WNT11	RGD	RGD:621463
Felis catus	WNT11	VGNC	VGNC:67082
Others	WNT11	NCBI