OPRM1 - opioid receptor mu 1 Gene
Also Known as MOP; MOR; LMOR; MOR1; OPRM; M-OR-1
Species: Homo sapiens
About OPRM1
This gene has 23 transcripts (splice variants), 215 orthologues and 17 paralogues. Low expression observed in reference dataset.
Summary
This gene encodes one of at least three opioid receptors in humans; the mu Opioid Receptor (MOR). The MOR is the principal target of endogenous opioid peptides and opioid analgesic agents such as beta-endorphin and enkephalins. The MOR also has an important role in dependence to Other drugs of abuse, such as nicotine, cocaine, and alcohol via its modulation of the dopamine system. The NM_001008503.2:c.118A>G allele has been associated with opioid and alcohol addiction and variations in pain sensitivity but evidence for it having a causal role is conflicting. Multiple transcript variants encoding different isoforms have been found for this gene. Though the canonical MOR belongs to the superfamily of 7-transmembrane-spanning G-protein-coupled receptors some isoforms of this gene have only 6 transmembrane domains. [provided by RefSeq, Oct 2013]
OPRM1 Products (19)
| mRNA | Protein | Name |
|---|---|---|
| NM_000914.5 | NP_000905.3 | mu-type opioid receptor isoform MOR-1 |
| NM_001008503.3 | NP_001008503.2 | mu-type opioid receptor isoform MOR-1O |
| NM_001008504.4 | NP_001008504.2 | mu-type opioid receptor isoform MOR-1A |
| NM_001008505.2 | NP_001008505.2 | mu-type opioid receptor isoform MOR-1X |
| NM_001145279.4 | NP_001138751.1 | mu-type opioid receptor isoform MOR-1i |
| NM_001145280.4 | NP_001138752.1 | mu-type opioid receptor isoform MOR-1G1 |
| NM_001145281.3 | NP_001138753.1 | mu-type opioid receptor isoform MOR-1G2 |
| NM_001145282.2 | NP_001138754.1 | mu-type opioid receptor isoform MOR-1B1 |
| NM_001145283.2 | NP_001138755.1 | mu-type opioid receptor isoform MOR-1B2 |
| NM_001145284.3 | NP_001138756.1 | mu-type opioid receptor isoform MOR-1B3 |
| NM_001145285.3 | NP_001138757.1 | mu-type opioid receptor isoform MOR-1B4 |
| NM_001145286.3 | NP_001138758.1 | mu-type opioid receptor isoform MOR-1B5 |
| NM_001145287.3 | NP_001138759.1 | mu-type opioid receptor isoform MOR-1G1 |
| NM_001285522.1 | NP_001272451.1 | mu-type opioid receptor isoform MOR-1S |
| NM_001285523.3 | NP_001272452.1 | mu-type opioid receptor isoform MOR-1A2 |
| NM_001285524.1 | NP_001272453.1 | mu-type opioid receptor isoform MOR-1i |
| NM_001285526.2 | NP_001272455.1 | mu-type opioid receptor isoform MOR-1G1 |
| NM_001285527.1 | NP_001272456.1 | mu-type opioid receptor isoform MOR-1W |
| NM_001285528.2 | NP_001272457.1 | mu-type opioid receptor isoform MOR-3 |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables G-protein alpha-subunit binding |
IDA
IDA: Inferred from direct assay
|
20214800 | GOA |
| enables beta-endorphin receptor activity |
IMP
IMP: Inferred from mutant phenotype
|
9689128 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
14573758 | GOA |
OPRM1 Protein Structure
7tm_1: 7 transmembrane receptor (rhodopsin family) (87 - 338)
- 0
- 100
- 200
- 300
- 400 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
mu-type opioid receptor |
|
OPRM1 Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
OPRM1 | P35372 | AUP1 | Homo sapiens | Q9Y679 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | AUP1 | Homo sapiens | Q9Y679 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | AUP1 | Homo sapiens | Q9Y679 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | VAPA | Homo sapiens | Q9P0L0 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | WLS | Homo sapiens | Q5T9L3 | 20214800 | |
|
Intra
|
OPRM1 | P35372 | WLS | Homo sapiens | Q5T9L3 | 20214800 | |
|
Intra
|
OPRM1 | P35372 | WLS | Homo sapiens | Q5T9L3 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | WLS | Homo sapiens | Q5T9L3 | 20214800 | |
|
Intra
|
OPRM1 | P35372 | WLS | Homo sapiens | Q5T9L3 | 20214800 | |
|
Intra
|
OPRM1 | P35372 | FLNA | Homo sapiens | P21333 | 14573758 | |
|
Intra
|
OPRM1 | P35372 | FLNA | Homo sapiens | P21333 | 14573758 | |
|
Intra
|
OPRM1 | P35372 | ZYX | Homo sapiens | Q15942 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | ZYX | Homo sapiens | Q15942 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | NELFA | Homo sapiens | Q9H3P2 | 28298427 | |
|
Intra
|
OPRM1 | P35372 | RANBP9 | Homo sapiens | Q96S59 | 19788913 | |
|
Intra
|
OPRM1 | P35372 | RANBP9 | Homo sapiens | Q96S59 | 19788913 | |
|
Intra
|
OPRM1 | P35372 | P01210-PRO_0000008243 | Homo sapiens | P01210-PRO_0000008243 | 23597562 | |
|
Intra
|
OPRM1 | P35372 | DOK4 | Homo sapiens | Q8TEW6 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | DOK4 | Homo sapiens | Q8TEW6 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | DOK4 | Homo sapiens | Q8TEW6 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | GJA4 | Homo sapiens | P35212 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | SIAH1 | Homo sapiens | Q8IUQ4 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | SIAH1 | Homo sapiens | Q8IUQ4 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | SIAH1 | Homo sapiens | Q8IUQ4 | 23840749 | |
|
Intra
|
OPRM1 | P35372 | SIAH2 | Homo sapiens | O43255 | 23840749 |
OPRM1 Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P811024 | Mu Opioid Receptor Antibody | WB, IHC-P, ICC/IF | Human, Mouse, Rat |
| HY-P811139 | Mu Opioid Receptor/ MOR1 Antibody | WB, IHC-P | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pertussis |
|
|
| Substance Dependence |
|
|
| Drug Dependence |
|
|
| Neonatal Abstinence Syndrome |
|
|
| Withdrawal Disorder |
|
|
| Opiate Dependence |
|
|
| Heroin Dependence |
|
|
| Pain Agnosia |
|
|
| Morphine Dependence |
|
|
| Alcohol Dependence |
|
|
| Ileus |
|
|
| Cocaine Dependence |
|
|
| Opioid Abuse |
|
|
| Agnosia |
|
|
| Constipation |
|
|
| Fibromyalgia |
|
|
| Familial Hemiplegic Migraine |
|
|
| Chronic Pain |
|
|
| Eating Disorder |
|
|
| Alcohol Use Disorder |
|
|
| Major Depressive Disorder |
|
|
| Specific Developmental Disorder |
|
|
| Tobacco Addiction |
|
|
| Migraine With Aura |
|
|
| Arthritis |
|
|
| Speech And Communication Disorders |
|
|
| Temporal Lobe Epilepsy |
|
|
| Hepatic Encephalopathy |
|
|
| Barbiturate Abuse |
|
|
| Substance Abuse |
|
|
| Somatoform Disorder |
|
|
| Anxiety |
|
|
| Pathological Gambling |
|
|
| Osteogenesis Imperfecta, Type Xi |
|
|
| Mucopolysaccharidosis, Type Iva |
|
|
| Paine Syndrome |
|
|
| Complex Regional Pain Syndrome |
|
|
| Cocaine Abuse |
|
|
| Amnestic Disorder |
|
|
| Impulse Control Disorder |
|
|
| Mucopolysaccharidosis Iv |
|
|
| Fallopian Tube Clear Cell Adenocarcinoma |
|
|
| Motion Sickness |
|
|
| Epilepsy, Idiopathic Generalized |
|
|
| Myasthenic Syndrome, Congenital, 3a, Slow-Channel |
|
|
| Disease Of Mental Health |
|
|
| Trigeminal Nerve Disease |
|
|
| Childhood Absence Epilepsy |
|
|
| Psychotic Disorder |
|
|
| Bipolar Disorder |
|
|
| Mucocele Of Appendix |
|
|
| Schizophrenia |
|
|
| Epilepsy |
|
|
| Migraine With Or Without Aura 1 |
|
|
| Attention Deficit-Hyperactivity Disorder |
|
|
| Alzheimer Disease, Familial, 1 |
|
|
| Parkinson Disease, Late-Onset |
|
|
| Peripheral Nervous System Disease |
|
|
| Type 2 Diabetes Mellitus |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Canis familiaris | OPRM1 | VGNC | VGNC:110521 |
| Macaca mulatta | OPRM1 | VGNC | VGNC:83440 |
| Rattus norvegicus | OPRM1 | RGD | RGD:3234 |
| Felis catus | OPRM1 | VGNC | VGNC:68635 |
| Mus musculus | OPRM1 | MGD | MGI:97441 |
| Bos taurus | OPRM1 | VGNC | VGNC:50239 |
| Others | OPRM1 | NCBI |