2. Gene
  3. RSAD2 - radical S-adenosyl methionine domain containing 2 Gene

RSAD2 - radical S-adenosyl methionine domain containing 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as cig5; vig1; cig33

Gene ID: 91543 | Gene type: protein coding

About RSAD2

Cytogenetic location: 2p25.2 Genomic coordinates (GRCh38): 2:6,865,885-6,898,239 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in spleen (RPKM 6.0), lung (RPKM 5.3) and 24 other tissues.

Summary

The protein encoded by this gene is an interferon-inducible Antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of enzymes. The protein plays a role in cellular Antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to Viral Proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including Influenza Virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]

RSAD2 Products(2)

mRNA Protein Name
NM_001410702.1 NP_001397631.1 radical S-adenosyl methionine domain-containing protein 2 isoform 2
NM_080657.5 NP_542388.2 radical S-adenosyl methionine domain-containing protein 2 isoform 1

RSAD2 Protein Structure

Fer4_12

Fer4_12: 4Fe-4S single cluster domain (78 - 176)

Radical_SAM

Radical_SAM: Radical SAM superfamily (79 - 209)

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  • 361 a.a.
Protein Preferred Names Protein Names

radical S-adenosyl methionine domain-containing protein 2

cytomegalovirus-induced gene 5 protein

Related Diseases

Diseases Alias
Yellow Fever

Urban Yellow Fever

Jungle Yellow Fever

Sylvatic Yellow Fever

Yf

Yellow Fever, Sylvan

Bronze John

Yellow Jack

Yf- [Yellow Fever]

Febris Flava
Chikungunya

Chikungunya Fever

Arbovirus A Chikungunya Type

Chik

Chikv Infection

Ck

Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever
Stomatitis
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Japanese Encephalitis

Japanese B Encephalitis

Je

Encephalitis Japanese

Encephalitis, Japanese

Russian Autumnal Encephalitis

Je - [Japanese Encephalitis]

Japanese Encephalitis Virus Disease

Jbe - [Japanese B Encephalitis}

B Type Encephalitis
Encephalitis

Mumps Encephalitis

Mumps Meningoencephalitis

Herpes Simplex Neuroinvasion

Herpetic Encephalitis

Herpetic Encephalopathy

Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis

Encephalitis Due To Herpesviridae

Encephalitis Due To Herpesvirus

Herpes Encephalitis

Herpesviral Encephalitis

Herpes Simplex Encephalitis

Hsv - [Herpes Simplex Virus] Encephalitis

Herpes Virus Encephalitis

Simian B Disease

Simian B Disorder

Encephalitis Nec

Idiopathic Encephalitis
West Nile Virus

West Nile Virus, Susceptibility To

Wnv

Wnv, Susceptibility To

West Nile Viral Infection

Encephalitis, West Nile Fever

West Nile Fever
Dengue Virus

Dengue Virus, Susceptibility To

Dengue Fever, Protection Against

Dengue Fever
Herpes Simplex

Herpes Simplex Infections

Herpesvirus Hominis Disease

Herpes Simplex Disease

Herpesviral Infection Due To Herpes Simplex

Infections Due To Simplex Virus

Herpes Nos
Microphthalmia With Limb Anomalies

Waardenburg Anophthalmia Syndrome

Ophthalmoacromelic Syndrome

OAS

MLA

Anophthalmia-Syndactyly

Anophthalmia-Syndactyly Syndrome

Anophthalmos With Limb Anomalies

Anophthalmia Waardenburg Syndrome

Anophthalmos-Syndactyly

Ophthalmo-Acromelic Syndrome

Anophthalmia-Waardenburg Syndrome

Anophthalmos-Limb Anomalies Syndrome

Syndactyly-Anophthalmos Syndrome

Microphthalmia, With Limb Anomalies
Human Cytomegalovirus Infection

Cytomegalovirus Infection

Cytomegalovirus Infections
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS12297 RSAD2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RSAD2 MGD MGI:1929628
Rattus norvegicus RSAD2 RGD RGD:620495
Bos taurus RSAD2 VGNC VGNC:34176
Macaca mulatta RSAD2 VGNC VGNC:77143
Canis familiaris RSAD2 VGNC VGNC:45770
Felis catus RSAD2 VGNC VGNC:81214