RSAD2 - radical S-adenosyl methionine domain containing 2 Gene

Also Known as cig5; vig1; cig33

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 91543

About RSAD2

Cytogenetic location: 2p25.2 Genomic coordinates (GRCh38): 2:6,865,885-6,898,239 (from NCBI)

This gene has 9 transcripts (splice variants) and 207 orthologues. Ubiquitous expression in spleen (RPKM 6.0), lung (RPKM 5.3) and 24 other tissues.

Summary

The protein encoded by this gene is an interferon-inducible Antiviral protein that belongs to the S-adenosyl-L-methionine (SAM) superfamily of Enzymes. The protein plays a role in cellular Antiviral response and innate immune signaling. Antiviral effects result from inhibition of viral RNA replication, interference in the secretory pathway, binding to Viral Proteins and dysregulation of cellular lipid metabolism. The protein has been found to inhibit both DNA and RNA viruses, including Influenza Virus, human immunodeficiency virus (HIV-1) and Zika virus. [provided by RefSeq, Sep 2020]

RSAD2 Products (2)

mRNA	Protein	Name
NM_001410702.1	NP_001397631.1	radical S-adenosyl methionine domain-containing protein 2 isoform 2
NM_080657.5	NP_542388.2	radical S-adenosyl methionine domain-containing protein 2 isoform 1

RSAD2 Protein Structure

Fer4_12

Radical_SAM

0
100
200
300
361 a.a.

Protein Preferred Names	Protein Names
radical S-adenosyl methionine domain-containing protein 2	cytomegalovirus-induced gene 5 protein

RSAD2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RSAD2	Q8WXG1	VAPA	Homo sapiens	Q9P0L0	Anti Tag CoIP	21957124
Intra	RSAD2	Q8WXG1	VAPA	Homo sapiens	Q9P0L0	Confocal	22045669
Intra	RSAD2	Q8WXG1	VAPA	Homo sapiens	Q9P0L0	FRET	22045669
Intra	RSAD2	Q8WXG1	APOC1	Homo sapiens	P02654	Y2H Array	32296183
Intra	RSAD2	Q8WXG1	APOC1	Homo sapiens	P02654	Y2H Prey Pooling	32296183
Intra	RSAD2	Q8WXG1	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Array	32296183
Intra	RSAD2	Q8WXG1	RHBDD2	Homo sapiens	Q6NTF9-3	Y2H Prey Pooling	32296183
Intra	RSAD2	Q8WXG1	APOC4	Homo sapiens	P55056	Y2H Prey Pooling	32296183
Intra	RSAD2	Q8WXG1	APOC4	Homo sapiens	P55056	Y2H Array	32296183
Intra	RSAD2	Q8WXG1	CIAO1	Homo sapiens	O76071	Anti Bait CoIP	24245804

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Yellow Fever	Urban Yellow Fever Jungle Yellow Fever Sylvatic Yellow Fever Yf Yellow Fever, Sylvan Bronze John Yellow Jack Yf- [Yellow Fever] Febris Flava
Chikungunya	Chikungunya Fever Arbovirus A Chikungunya Type Chik Chikv Infection Ck Chikungunya Virus Infection Chikungunya Haemorrhagic Fever Chikungunya Viral Disease Chikungunya Mosquito-Borne Viral Fever
Stomatitis
Influenza	Flu Influenza With Non-Respiratory Manifestation Influenza With Other Manifestations Influenza, Human Influenza, Susceptibility To Seasonal Influenza, Virus Identified
Japanese Encephalitis	Japanese B Encephalitis Je Encephalitis Japanese Encephalitis, Japanese Russian Autumnal Encephalitis Je - [Japanese Encephalitis] Japanese Encephalitis Virus Disease Jbe - [Japanese B Encephalitis} B Type Encephalitis
Encephalitis	Mumps Encephalitis Mumps Meningoencephalitis Herpes Simplex Neuroinvasion Herpetic Encephalitis Herpetic Encephalopathy Herpes Simplex Encephalitis, Myelitis Or Encephalomyelitis Encephalitis Due To Herpesviridae Encephalitis Due To Herpesvirus Herpes Encephalitis Herpesviral Encephalitis Herpes Simplex Encephalitis Hsv - [Herpes Simplex Virus] Encephalitis Herpes Virus Encephalitis Simian B Disease Simian B Disorder Encephalitis Nec Idiopathic Encephalitis
West Nile Virus	West Nile Virus, Susceptibility To Wnv Wnv, Susceptibility To West Nile Viral Infection Encephalitis, West Nile Fever West Nile Fever
Dengue Virus	Dengue Virus, Susceptibility To Dengue Fever, Protection Against Dengue Fever
Herpes Simplex	Herpes Simplex Infections Herpesvirus Hominis Disease Herpes Simplex Disease Herpesviral Infection Due To Herpes Simplex Infections Due To Simplex Virus Herpes Nos
Microphthalmia With Limb Anomalies	Waardenburg Anophthalmia Syndrome Ophthalmoacromelic Syndrome OAS MLA Anophthalmia-Syndactyly Anophthalmia-Syndactyly Syndrome Anophthalmos With Limb Anomalies Anophthalmia Waardenburg Syndrome Anophthalmos-Syndactyly Ophthalmo-Acromelic Syndrome Anophthalmia-Waardenburg Syndrome Anophthalmos-Limb Anomalies Syndrome Syndactyly-Anophthalmos Syndrome Microphthalmia, With Limb Anomalies
Human Cytomegalovirus Infection	Cytomegalovirus Infection Cytomegalovirus Infections
Aicardi-Goutieres Syndrome	Aicardi Goutieres Syndrome Cree Encephalitis Aicardi-Goutières Syndrome Encephalopathy With Basal Ganglia Calcification Ags Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid Pseudotoxoplasmosis Syndrome Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis Aicardi-Goutieres Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12297	RSAD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20486	Rsad2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26994	Rsad2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RSAD2	MGD	MGI:1929628
Rattus norvegicus	RSAD2	RGD	RGD:620495
Bos taurus	RSAD2	VGNC	VGNC:34176
Macaca mulatta	RSAD2	VGNC	VGNC:77143
Canis familiaris	RSAD2	VGNC	VGNC:45770
Felis catus	RSAD2	VGNC	VGNC:81214
Others	RSAD2	NCBI