APOC1 - apolipoprotein C1 Gene

Also Known as Apo-CI; ApoC-I; apo-CIB; apoC-IB

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 341

About APOC1

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:44,914,325-44,919,346 (from NCBI)

This gene has 9 transcripts (splice variants) and 58 orthologues. Biased expression in liver (RPKM 1936.2) and adrenal (RPKM 201.2).

Summary

This gene encodes a member of the Apolipoprotein C1 family. This gene is expressed primarily in the liver, and it is activated when monocytes differentiate into macrophages. The encoded protein plays a central role in high density lipoprotein (HDL) and very low density lipoprotein (VLDL) metabolism. This protein has also been shown to inhibit cholesteryl ester transfer protein in plasma. A pseudogene of this gene is located 4 kb downstream in the same orientation, on the same chromosome. This gene is mapped to chromosome 19, where it resides within a Apolipoprotein gene cluster. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Sep 2016]

APOC1 Products (8)

mRNA	Protein	Name
NM_001321066.2	NP_001307995.1	apolipoprotein C-I isoform a precursor
NM_001379687.1	NP_001366616.1	apolipoprotein C-I isoform b precursor
NM_001645.5	NP_001636.1	apolipoprotein C-I isoform a precursor
NM_001321065.2	NP_001307994.1	apolipoprotein C-I isoform a precursor
NM_001321065.2	NP_001307994.1	apolipoprotein C-I isoform a precursor
NM_001321066.2	NP_001307995.1	apolipoprotein C-I isoform a precursor
NM_001379687.1	NP_001366616.1	apolipoprotein C-I isoform b precursor
NM_001645.5	NP_001636.1	apolipoprotein C-I isoform a precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables fatty acid binding	IDA IDA: Inferred from direct assay	17339654	GOA
enables lipase inhibitor activity	IDA IDA: Inferred from direct assay	182536	GOA
enables phospholipase inhibitor activity	IDA IDA: Inferred from direct assay	2302419	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in cholesterol efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in chylomicron remnant clearance	IDA IDA: Inferred from direct assay	4020294	GOA
involved in negative regulation of cholesterol transport	IDA IDA: Inferred from direct assay	10978346	GOA
involved in negative regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	15576844	GOA
involved in negative regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	15576844	GOA
involved in negative regulation of lipid metabolic process	IDA IDA: Inferred from direct assay	182536	GOA
involved in negative regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	15576844	GOA
involved in negative regulation of phosphatidylcholine catabolic process	IDA IDA: Inferred from direct assay	2302419	GOA
involved in negative regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	1917954	GOA
involved in negative regulation of very-low-density lipoprotein particle clearance	IDA IDA: Inferred from direct assay	1917954	GOA
involved in phospholipid efflux	IDA IDA: Inferred from direct assay	11162594	GOA
involved in plasma lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	10978346	GOA
involved in very-low-density lipoprotein particle clearance	IGI IGI: Inferred from genetic interaction	15576844	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	15576844	GOA
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	15576844	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOC1 Protein Structure

ApoC-I

0
83 a.a.

Protein Preferred Names	Protein Names
apolipoprotein C-I

APOC1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	APOC1	P02654	RTP5	Homo sapiens	Q14D33	Validated Y2H	32296183
Intra	APOC1	P02654	SYT16	Homo sapiens	Q17RD7	Validated Y2H	32296183
Intra	APOC1	P02654	TEX44	Homo sapiens	Q53QW1	Validated Y2H	32296183
Intra	APOC1	P02654	H4C7	Homo sapiens	Q99525	Validated Y2H	32296183
Intra	APOC1	P02654	MAIP1	Homo sapiens	Q8WWC4	Validated Y2H	32296183
Intra	APOC1	P02654	MICOS13	Homo sapiens	Q5XKP0	Validated Y2H	32296183
Intra	APOC1	P02654	GSDMA	Homo sapiens	Q96QA5	Validated Y2H	32296183
Intra	APOC1	P02654	FOXD4L3	Homo sapiens	Q6VB84	Validated Y2H	32296183
Intra	APOC1	P02654	ACACA	Homo sapiens	Q13085-4	Validated Y2H	32296183
Intra	APOC1	P02654	RSAD2	Homo sapiens	Q8WXG1	Validated Y2H	32296183
Intra	APOC1	P02654	LETMD1	Homo sapiens	Q6P1Q0	Validated Y2H	32296183
Intra	APOC1	P02654	TPRG1	Homo sapiens	Q6ZUI0	Validated Y2H	32296183
Intra	APOC1	P02654	MP68	Homo sapiens	P56378-2	Validated Y2H	32296183
Intra	APOC1	P02654	ACSF2	Homo sapiens	Q96CM8	Validated Y2H	32296183
Intra	APOC1	P02654	DHRSX	Homo sapiens	Q8N5I4	Validated Y2H	32296183
Intra	APOC1	P02654	MTCH2	Homo sapiens	Q9Y6C9	Validated Y2H	32296183
Intra	APOC1	P02654	CIDEB	Homo sapiens	Q9UHD4	Validated Y2H	32296183
Intra	APOC1	P02654	BCL2L2	Homo sapiens	Q92843	Validated Y2H	32296183
Intra	APOC1	P02654	NFU1	Homo sapiens	Q9UMS0	Validated Y2H	32296183
Intra	APOC1	P02654	SPG21	Homo sapiens	Q9NZD8	Validated Y2H	32296183
Intra	APOC1	P02654	RADIL	Homo sapiens	Q96JH8	Validated Y2H	32296183
Intra	APOC1	P02654	MTERF3	Homo sapiens	Q96E29	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

APOC1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82603	ApoC1 Antibody (YA2348)	WB, IHC-P, ICC/IF, IP, FC	Human

Related Diseases

Diseases	Alias
Malignant Ovarian Cyst
Adermatoglyphia	ADERM Immigration Delay Disease Absence Of Fingerprints Adg Congenital Absence Of Fingerprints Isolated Congenital Adermatoglyphia Fingerprints, Absence Of Skin Abnormalities
Aphasia
Dementia	Dementias Presenile Dementia Alzheimer Type Dementia Alzheimer Sclerosis Alzheimer Disease Dementia Alzheimer Dementia Primary Degenerative Alzheimer Type Dementia End Stage Alzheimer'S Dementia Alzheimer'S Type Atypical Dementia Alzheimer Type Presenile Dementia Early Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 2 Dementia In Alzheimer Disease With Early Onset Early Onset Alzheimer Type Dementia, Uncomplicated Primary Degenerative Alzheimer Type Dementia, Early Onset Primary Degenerative Alzheimer Type Dementia, Presenile Onset, Uncomplicated Alzheimer Disease Dementia With Early Onset Presenile Sclerosis Presenile Brain Sclerosis Presenile Alzheimer Brain Sclerosis Late Onset Alzheimer Dementia Dementia In Alzheimer Disease Type 1 Dementia In Alzheimer Disease With Late Onset Primary Degenerative Alzheimer Type Dementia, Late Onset Sdat - [Senile Dementia, Alzheimer Type] Alzheimer Disease Dementia With Late Onset Late Onset Alzheimer Brain Sclerosis Senile Alzheimer Brain Disease Senile Alzheimer Brain Sclerosis Senile Primary Degenerative Alzheimer Type Dementia Senile Dementia Of The Alzheimer Type Arteriosclerotic Dementia Strategic-Infarct Dementia Post Stroke Dementia Vascular Cognitive Impairment Vascular Dementia Dementia Of The Lewy Body Type Dementia With Lewy Bodies Sdlt - [Senile Dementia Of The Lewy Body Type] Senile Dementia Of The Lewy Body Type Alcohol-Related Dementia Alcoholic Dementia Nos Alcohol-Induced Dementia Alcoholic Brain Syndrome Chronic Alcoholic Brain Syndrome Alcohol Dementia Late Onset Alcoholic Psychosis Residual And Late-Onset Alcohol-Induced Psychotic Disorder Mental And Behavioural Disorders Due To Use Of Sedatives Or Hypnotics, Residual And Late-Onset Psychotic Disorder Late-Onset Psychoactive Substance-Induced Psychotic Disorder Inhalant Dementia Volatile Solvents Dementia Dementia In Paralysis Agitans Pdd - [Parkinson Disease Dementia] Dementia Syndrome Of Parkinson Disease Dementia In Parkinson Disease Parkinson Related Dementia Dementia In Huntington Chorea Hiv - [Human Immunodeficiency Virus] Dementia Hiv- [Human Immunodeficiency Virus] Associated Cognitive Motor Complex Hiv- [Human Immunodeficiency Virus] Associated Dementia Complex Aids - [Acquired Immunodeficiency Syndrome] Dementia Complex Aids Related Dementia Dementia Due To Niacin Deficiency
Frontotemporal Dementia	Pallidopontonigral Degeneration Frontotemporal Lobar Degeneration Semantic Dementia FTD Frontotemporal Lobe Dementia Multiple System Tauopathy With Presenile Dementia Dementia, Frontotemporal Frontotemporal Dementia With Parkinsonism Mstd Frontotemporal Lobar Degeneration With Tau Inclusions Ftld With Tau Inclusions Dementia, Frontotemporal, With Parkinsonism Fldem Ftdp17 Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex Ddpac Wilhelmsen-Lynch Disease Wld Ppnd Dementia, Frontotemporal, With Or Without Parkinsonism Semantic Primary Progressive Aphasia Semantic Variant Ppa Wilhemsen-Lynch Disease Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17 Ftd-Als Ftld Pick Complex Pick Disease Of The Brain Frontotemporal Dementia With Parkinsonism-17 Grn-Related Frontotemporal Dementia Frontotemporal Dementia With Motor Neuron Disease Dementia In Fronto-Temporal Lobar Degeneration Ftd - [Frontotemporal Dementia] Temple Dementia Frontal Lobe Dementia
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00844	APOC1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	APOC1	RGD	RGD:2134
Macaca mulatta	APOC1	VGNC	VGNC:103787
Mus musculus	APOC1	MGD	MGI:88053
Canis familiaris	APOC1	VGNC	VGNC:37999
Others	APOC1	NCBI