MAIP1 - matrix AAA peptidase interacting protein 1 Gene

Also Known as C2orf47

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79568

Summary

Predicted to enable ribosome binding activity. Involved in calcium import into the mitochondrion; mitochondrial calcium ion homeostasis; and protein insertion into mitochondrial membrane. Located in mitochondrial matrix. [provided by Alliance of Genome Resources, Jul 2025]
Ubiquitous expression in kidney (RPKM 12.0), liver (RPKM 9.3) and 25 other tissues.

MAIP1 Products (3)

mRNA Protein Name
NM_001369399.1 NP_001356328.1 m-AAA protease-interacting protein 1, mitochondrial isoform 2
NM_001394955.1 NP_001381884.1 m-AAA protease-interacting protein 1, mitochondrial isoform 1 precursor
NM_024520.3 NP_078796.2 m-AAA protease-interacting protein 1, mitochondrial isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
27642048 GOA
Biological Process GO Annotation Evidence References Source
involved in calcium import into the mitochondrion IMP
IMP: Inferred from mutant phenotype
27642048 GOA
involved in mitochondrial calcium ion homeostasis IMP
IMP: Inferred from mutant phenotype
27642048 GOA
involved in protein insertion into mitochondrial membrane IMP
IMP: Inferred from mutant phenotype
27642048 GOA
Cellular Component GO Annotation Evidence References Source
located in mitochondrial matrix IDA
IDA: Inferred from direct assay
27642048 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MAIP1 Q8WWC4 H4C7 Homo sapiens Q99525
Y2H Array
32296183
Intra
MAIP1 Q8WWC4 H4C7 Homo sapiens Q99525
Y2H Prey Pooling
32296183
Intra
MAIP1 Q8WWC4 H4C7 Homo sapiens Q99525
Validated Y2H
32296183
Intra
MAIP1 Q8WWC4 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra
MAIP1 Q8WWC4 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra
MAIP1 Q8WWC4 APOC4 Homo sapiens P55056
Y2H Array
32296183
Intra
MAIP1 Q8WWC4 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Phase
HY-P99246 Bermekimab Inhibitor 97.68% Phase 3

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08159 MASP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS09981 PAIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10758 PMAIP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17421 Masp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20580 Pmaip1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23876 Masp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27088 Pmaip1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown