GSDMA - gasdermin A Gene

Also Known as GSDM; FKSG9; GSDM1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 284110

About GSDMA

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:39,963,004-39,977,768 (from NCBI)

This gene has 3 transcripts (splice variants), 194 orthologues and 4 paralogues. Biased expression in skin (RPKM 16.4) and esophagus (RPKM 1.0).

Summary

Predicted to enable phosphatidylinositol-4,5-bisphosphate binding activity; phosphatidylinositol-4-phosphate binding activity; and phosphatidylserine binding activity. Involved in apoptotic process. Located in perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

GSDMA Products (1)

mRNA Protein Name
NM_178171.5 NP_835465.2 gasdermin-A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables wide pore channel activity IDA
IDA: Inferred from direct assay
35110732 GOA
Biological Process GO Annotation Evidence References Source
involved in defense response to bacterium IDA
IDA: Inferred from direct assay
35110732 GOA
involved in pyroptotic inflammatory response IDA
IDA: Inferred from direct assay
35110732 GOA
Cellular Component GO Annotation Evidence References Source
is active in membrane IDA
IDA: Inferred from direct assay
35110732 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17471240 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GSDMA Protein Structure

Gasdermin

Gasdermin: Gasdermin family (3 - 420)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 445 a.a.
Protein Preferred Names Protein Names

gasdermin-A

  • gasdermin-1

GSDMA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
GSDMA Q96QA5 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra
GSDMA Q96QA5 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra
GSDMA Q96QA5 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
Intra
GSDMA Q96QA5 APOC4 Homo sapiens P55056
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inflammatory Bowel Disease 22

  • IBD22
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05854 GSDMA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20417 Gsdma Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26926 Gsdma Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus GSDMA RGD RGD:1592062
Felis catus GSDMA VGNC VGNC:62725
Macaca mulatta GSDMA VGNC VGNC:104606
Bos taurus GSDMA VGNC VGNC:49998
Canis familiaris GSDMA VGNC VGNC:54951
Others GSDMA NCBI