LETMD1 - LETM1 domain containing 1 Gene

Also Known as HCCR; HCCR1; HCCR2; HCCR-1; HCCR-2; HCRR-2; SLC55A3; 1110019O13Rik

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 25875

About LETMD1

Cytogenetic location: 12q13.12 Genomic coordinates (GRCh38): 12:51,048,220-51,068,958 (from NCBI)

This gene has 38 transcripts (splice variants), 215 orthologues and 2 paralogues. Ubiquitous expression in thyroid (RPKM 15.5), fat (RPKM 12.3) and 25 other tissues.

Summary

This gene encodes a mitochondrial outer membrane protein. It has a potential role in tumorigenesis, which may result from negative regulation of the p53 tumor suppressor gene. Alternatively spliced transcript variants have been noted for this gene. [provided by RefSeq, Aug 2011]

LETMD1 Products (25)

mRNA Protein Name
NM_001243689.2 NP_001230618.1 LETM1 domain-containing protein 1 isoform b
NM_001300765.2 NP_001287694.1 LETM1 domain-containing protein 1 isoform c
NM_001351312.2 NP_001338241.1 LETM1 domain-containing protein 1 isoform d
NM_001351313.2 NP_001338242.1 LETM1 domain-containing protein 1 isoform e
NM_001351315.2 NP_001338244.1 LETM1 domain-containing protein 1 isoform f
NM_001351316.2 NP_001338245.1 LETM1 domain-containing protein 1 isoform g
NM_001351317.2 NP_001338246.1 LETM1 domain-containing protein 1 isoform h
NM_001351319.2 NP_001338248.1 LETM1 domain-containing protein 1 isoform d
NM_001351320.2 NP_001338249.1 LETM1 domain-containing protein 1 isoform k
NM_001351321.2 NP_001338250.1 LETM1 domain-containing protein 1 isoform l
NM_001351322.2 NP_001338251.1 LETM1 domain-containing protein 1 isoform m
NM_001351323.2 NP_001338252.1 LETM1 domain-containing protein 1 isoform m
NM_001351324.2 NP_001338253.1 LETM1 domain-containing protein 1 isoform m
NM_001351325.2 NP_001338254.1 LETM1 domain-containing protein 1 isoform n
NM_001351326.2 NP_001338255.1 LETM1 domain-containing protein 1 isoform o
NM_001351327.2 NP_001338256.1 LETM1 domain-containing protein 1 isoform o
NM_001351328.2 NP_001338257.1 LETM1 domain-containing protein 1 isoform p
NM_001351330.2 NP_001338259.1 LETM1 domain-containing protein 1 isoform t
NM_001351332.2 NP_001338261.1 LETM1 domain-containing protein 1 isoform u
NM_001351333.2 NP_001338262.1 LETM1 domain-containing protein 1 isoform q
NM_001351334.2 NP_001338263.1 LETM1 domain-containing protein 1 isoform e
NM_001351335.2 NP_001338264.1 LETM1 domain-containing protein 1 isoform e
NM_001351336.2 NP_001338265.1 LETM1 domain-containing protein 1 isoform e
NM_001351337.2 NP_001338266.1 LETM1 domain-containing protein 1 isoform s
NM_015416.5 NP_056231.3 LETM1 domain-containing protein 1 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16762630 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of inflammatory response IMP
IMP: Inferred from mutant phenotype
31980577 GOA
involved in regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
31980577 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LETMD1 Protein Structure

LETM1

LETM1: LETM1-like protein (79 - 346)

  • 0
  • 100
  • 200
  • 300
  • 360 a.a.
Protein Preferred Names Protein Names

LETM1 domain-containing protein 1

  • cervical cancer 1 proto-oncogene protein p40

LETMD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LETMD1 Q6P1Q0 APOC1 Homo sapiens P02654
Y2H Array
32296183
Intra
LETMD1 Q6P1Q0 APOC1 Homo sapiens P02654
Y2H Prey Pooling
32296183
Intra
LETMD1 Q6P1Q0 REEP5 Homo sapiens Q00765
Y2H
16762630
Intra
LETMD1 Q6P1Q0 REEP5 Homo sapiens Q00765
Pull Down
16762630
Intra
LETMD1 Q6P1Q0 REEP5 Homo sapiens Q00765
Anti Tag CoIP
16762630
Intra
LETMD1 Q6P1Q0 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Prey Pooling
32296183
Intra
LETMD1 Q6P1Q0 RHBDD2 Homo sapiens Q6NTF9-3
Y2H Array
32296183
Intra
LETMD1 Q6P1Q0 TMEM167B Homo sapiens Q9NRX6
Y2H Array
32296183
Intra
LETMD1 Q6P1Q0 TMEM167B Homo sapiens Q9NRX6
Y2H Prey Pooling
32296183
Intra
LETMD1 Q6P1Q0 TMEM167B Homo sapiens Q9NRX6
Validated Y2H
32296183
Intra
LETMD1 Q6P1Q0 APOC4 Homo sapiens P55056
Y2H Prey Pooling
32296183
Intra
LETMD1 Q6P1Q0 APOC4 Homo sapiens P55056
Y2H Array
32296183
Intra
LETMD1 Q6P1Q0 BRI3BP Homo sapiens Q8WY22
Anti Tag CoIP
17943721
Intra
LETMD1 Q6P1Q0 BRI3BP Homo sapiens Q8WY22
Anti Bait CoIP
17943721
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cervical Cancer

  • Cervical Cancer, Somatic

  • Neoplasm Of Uterine Cervix

  • Cervix Cancer

  • Uterine Cervical Neoplasm

  • Cervical Neoplasm

  • Cervix Uteri Cancer

  • Tumor Of The Cervix Uteri

  • CERCA

  • Uterine Cervical Cancer

  • Neoplasms Cervical

  • Uterine Cervical Neoplasms

  • Cervical Cancers

  • Cancer, Cervical, Somatic

  • Malignant Tumor Of Cervix

  • Cervix Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07599 LETMD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta LETMD1 VGNC VGNC:74109
Felis catus LETMD1 VGNC VGNC:63216
Canis familiaris LETMD1 VGNC VGNC:42643
Rattus norvegicus LETMD1 RGD RGD:1596738
Mus musculus LETMD1 MGD MGI:1915864
Bos taurus LETMD1 VGNC VGNC:30847
Others LETMD1 NCBI