2. Gene
  3. OSBP - oxysterol binding protein Gene

OSBP - oxysterol binding protein Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as OSBP1

Gene ID: 5007 | Gene type: protein coding

About OSBP

Cytogenetic location: 11q12.1 Genomic coordinates (GRCh38): 11:59,574,398-59,615,774 (from NCBI)

This gene has 3 transcripts (splice variants), 255 orthologues and 11 paralogues. Ubiquitous expression in adrenal (RPKM 22.9), kidney (RPKM 22.7) and 25 other tissues.

Summary

Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]

OSBP Products(1)

mRNA Protein Name
NM_002556.3 NP_002547.1 oxysterol-binding protein 1

OSBP Protein Structure

PH

PH: PH domain (91 - 178)

Oxysterol_BP

Oxysterol_BP: Oxysterol-binding protein (418 - 793)

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  • 807 a.a.
Protein Preferred Names Protein Names

oxysterol-binding protein 1

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 67

DFNA67

Autosomal Dominant Nonsyndromic Deafness 67

Autosomal Dominant Deafness 67

Deafness, Autosomal Dominant, 67

Deafness, Autosomal Dominant, Type 67
Nonparalytic Poliomyelitis

Acute Nonparalytic Poliomyelitis

Non-Paralytic Aseptic Meningitis
Amyotrophic Lateral Sclerosis 8

Amyotrophic Lateral Sclerosis Type 8

ALS8

Sclerosis, Lateral, Amyotrophic, Type Type 8
Acute Flaccid Myelitis
Acute Hemorrhagic Conjunctivitis

Viral Conjunctivitis

Conjunctivitis, Acute Hemorrhagic

Apollo Disease

Epidemic Hemorrhagic Conjunctivitis

Viral Conjunctiva Disorder

Viral Conjunctivitis Nos
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-17514 Itraconazole 99.81% Yes
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101213 OSW-1 98.84% Unkown
HY-124806 TTP-8307 Inhibitor 99.63% Unkown
HY-148391 23-Oxa-OSW-1 Inhibitor / Unkown
HY-156275 OSBP-IN-1 / Unkown
HY-17514S2 Itraconazole-d9 / Unkown
HY-RS09835 OSBP Human Pre-designed siRNA Set A / Unkown
HY-RS09836 OSBP2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus OSBP VGNC VGNC:32456
Canis familiaris OSBP VGNC VGNC:44149
Rattus norvegicus OSBP RGD RGD:1308069
Felis catus OSBP VGNC VGNC:68656
Mus musculus OSBP MGD MGI:97447
Macaca mulatta OSBP VGNC VGNC:75718