PFM067-N-morpholine
PFM067-N-morpholine is an OSBP inhibitor that binds to the ORD domain of the host lipid transfer protein, which is involved in HSV-2 replication. PFM067-N-morpholine has a Kd of 4.93 μM for human OSBP. PFM067-N-morpholine inhibits HSV-2 replication with a selectivity index, with an EC50 of 8 nM in Hela cells. PFM067-N-morpholine can be used for research on HSV-2 infection.
For research use only. We do not sell to patients.
- CAS No.: 241139-69-5
- Formula: C28H45NO3
- Molecular Weight:443.66
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
HSV-2 8 nM (EC50) |
OSBP 4.93 μM (Kd) |
In Vitro
PFM067-N-morpholine strongly reduces HSV-2 progeny virus production in HeLa cells and exhibits a superimposed inhibitory effect when OSBP is silenced[1].
PFM067-N-morpholine inhibits HRV-A1 replication in HeLa cells with an EC50 of 0.126 µM and shows no detectable inhibitory activity against AdV-5[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 241139-69-5
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Molecular Weight 443.66
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Formula C28H45NO3
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SMILES
C[C@H](CCC(N1CCOCC1)=O)[C@@]2([H])CC[C@@]3([H])[C@]4([H])CC=C5C[C@@H](O)CC[C@]5(C)[C@@]4([H])CC[C@]23C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PFM067-N-morpholine Related Classifications
HY-190480 Related Classifications
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