1. Metabolic Enzyme/Protease
  2. LXR
  3. DMHCA

DMHCA 

Cat. No.: HY-129098
Handling Instructions

DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects and can be used for the research of cholesterol homeostasis diabetes.

For research use only. We do not sell to patients.

DMHCA Chemical Structure

DMHCA Chemical Structure

CAS No. : 79066-03-8

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
5 mg USD 60 In-stock
Estimated Time of Arrival: December 31
10 mg USD 100 In-stock
Estimated Time of Arrival: December 31
25 mg USD 200 In-stock
Estimated Time of Arrival: December 31
50 mg USD 350 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

DMHCA, a potent and selective LXR agonist, specifically activates the cholesterol efflux arm of the LXR pathway without stimulating triglyceride synthesis. DMHCA has anti-inflammatory effects and can be used for the research of cholesterol homeostasis diabetes[1].

IC50 & Target

IC50: LXR[1]

In Vitro

In ex vivo treatment of diabetic CD34+ cells, DMHCA (10 µM; 16-18 hours) restores the fluidity of the membranes to baseline nondiabetic levels[1].
DMHCA restores the levels of BM-derived TNF-α and IL-3 to baseline and significantly reduces CCL-2 production by >50% in the BM supernatants and the systemic circulation compares to the control mice. DMHCA also increases the number of CACs in the BM and peripheral circulation and upregulates the egression of vascular reparative cells into the peripheral circulation[1].
In the PAGA analysis, DMHCA treatment enhances the overall production and robustness of erythrocyte progenitors. DMHCA enhances flux down the erythrocyte progenitor lineage. It also DMHCA increase in erythrocyte progenitor density in BM cells. DMHCA not only expands the proportion of erythrocyte progenitors but also increases the expression of the hemoglobin beta adult chain (HBB-BT)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DMHCA (oral administration; 6 months; chow 8mg/kg body weight /day) restores cholesterol homeostasis in diabetic retina. It significantly increases endogenous LXR ligands, desmosterol, and total oxysterols in the diabetic retina[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

401.63

Formula

C₂₆H₄₃NO₂

CAS No.
SMILES
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 7.69 mg/mL (19.15 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4899 mL 12.4493 mL 24.8985 mL
5 mM 0.4980 mL 2.4899 mL 4.9797 mL
10 mM 0.2490 mL 1.2449 mL 2.4899 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

DMHCALXRLiver X receptorInflammationdisease pathogenesisdb/dbHSCsBone marrowDiabetesInhibitorinhibitorinhibit

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DMHCA
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