79066-03-8
Chemical Structure
PFM067
Synonym(s): DMHCA
- CAS No.: 79066-03-8
- Formula:C26H43NO2
- Molecular Weight:401.63
IUPAC Name: (R)-4-((3S,8S,9S,10R,13R,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl)-N,N-dimethylpentanamide
InChIKey: NDGUBXOBXSPVHJ-LXVLQKCJSA-N
SMILES: C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCC(N(C)C)=O)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(C[C@H](CC4)O)=CC3)C
Biological Activity: PFM067 (DMHCA) is an orally active cholestenoic acid amide derivative. PFM067 exhibits antiviral activity against HSV‑2, HSV‑1, and HRV‑A1. PFM067 directly binds the ORD domain of human OSBP with a Kd of 3.96 μM. PFM067 blocks late HSV-2 replication, cell-to-cell fusion, syncytium formation, and infectious progeny production, retains glycoproteins in the cis-Golgi, and may block capsid nuclear egress. PFM067 agonizes LXRβ and inhibits DHCR24, restoring membrane fluidity in diabetic CD34+ cells and CAC cells. PFM067 protects retinal vascular/visual function in diabetic mice. PFM067 can be used in research related to herpesvirus infection and type 2 diabetes[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PFM067 | 99.91% | PFM067 (DMHCA) is an orally active cholestenoic acid amide derivative. PFM067 exhibits antiviral activity against HSV‑2, HSV‑1, and HRV‑A1. PFM067 directly binds the ORD domain of human OSBP with a Kd of 3.96 μM. PFM067 blocks late HSV-2 replication, cell-to-cell fusion, syncytium formation, and infectious progeny production, retains glycoproteins in the cis-Golgi, and may block capsid nuclear egress. PFM067 agonizes LXRβ and inhibits DHCR24, restoring membrane fluidity in diabetic CD34+ cells and CAC cells. PFM067 protects retinal vascular/visual function in diabetic mice. PFM067 can be used in research related to herpesvirus infection and type 2 diabetes. | ||||||||||||||||||||
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Similarity Score 0.88
HY-1133153b-Hydroxy-5-cholenoic acid -
Similarity Score 0.87
HY-100084Methyl-3β-hydroxycholenate -
Similarity Score 0.84
HY-U00424Chol-5-en-24-al-3β-ol -
Similarity Score 0.84
HY-13396824-Methylenecholesterol -
Similarity Score 0.83
HY-15786SGE-201 -
Similarity Score 0.83
HY-113224RDesmosterol (Standard) -
Similarity Score 0.82
HY-N4103Fucosterol -
Similarity Score 0.82
HY-N4103AΔ5-Avenasterol -
Similarity Score 0.82
HY-1339723β-Hydroxy-5-cholestenoic acid -
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References
- [1]. Civra A, et al. Identification of oxysterol synthetic analogs as a novel class of late-stage inhibitors of herpes simplex virus 2 replication. Antiviral Research, 2023, 215: 105634.
- [2]. Civra A, et al. Targeting oxysterol-binding protein (OSBP) as a novel strategy to inhibit herpes simplex virus 2 (HSV-2) replication: First structure-activity relationship study of antiviral cholenamide derivatives. European journal of medicinal chemistry. 2026 Nov 15;318:119195.
- [3]. Vieira C P, et al. Selective LXR agonist DMHCA corrects retinal and bone marrow dysfunction in type 2 diabetes. JCI Insight, 2020.
