2. Cell Cycle/DNA Damage Epigenetics Metabolic Enzyme/Protease
  3. PARP Endogenous Metabolite
  4. Fucosterol

Fucosterol 

Cat. No.: HY-N4103 Purity: ≥98.0%
COA Handling Instructions

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research.

For research use only. We do not sell to patients.

Fucosterol Chemical Structure

Fucosterol Chemical Structure

CAS No. : 17605-67-3

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5 mg USD 109 In-stock
10 mg USD 185 In-stock
20 mg USD 315 In-stock
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Based on 1 publication(s) in Google Scholar

Fucosterol Related Antibodies

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Description

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities[1][2]. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research[1].

IC50 & Target

PPARα; C/EBPα[1]
In Vitro

Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1]. Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3].
Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 μg/ml, respectively[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Fucosterol Related Antibodies

Cell Viability Assay[1]

Cell Line: 3T3-L1 adipocytes
Concentration: 0 μM; 25 μM; 50 μM
Incubation Time: 7 days
Result: Inhibited PPARα and C/EBPα expression.
In Vivo

Fucosterol (oral adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

412.69

Appearance

Solid

Formula

C29H48O
CAS No.
SMILES

C/C=C(C(C)C)/CC[C@@H](C)[C@H]1CC[C@@]2([H])[C@]3([H])CC=C4CC(O)CC[C@]4(C)[C@@]3([H])CC[C@]12C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 16.67 mg/mL (40.39 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4231 mL 12.1156 mL 24.2313 mL
5 mM 0.4846 mL 2.4231 mL 4.8463 mL
10 mM 0.2423 mL 1.2116 mL 2.4231 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  Corn Oil

    Solubility: 10 mg/mL (24.23 mM); Clear solution; Need ultrasonic and warming and heat to 45°C

  • 2.

    Add each solvent one by one:  17% Polyethylene glycol 12-hydroxystearate in Saline

    Solubility: 6.25 mg/mL (15.14 mM); Suspended solution; Need ultrasonic and warming and heat to 42°C

  • 3.

    Add each solvent one by one:  10% EtOH    90% Corn Oil

    Solubility: ≥ 1.67 mg/mL (4.05 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (248 KB) HNMR (233 KB)

Handling Instructions (2659 KB)
References
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Fucosterol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Fucosterol17605-67-3PARPEndogenous Metabolitepoly ADP ribose polymeraseInhibitorinhibitorinhibit

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