1. Cell Cycle/DNA Damage
    Epigenetics
    Metabolic Enzyme/Protease
  2. PARP
    Endogenous Metabolite
  3. Fucosterol

Fucosterol 

Cat. No.: HY-N4103 Purity: ≥98.0%
Handling Instructions

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research.

For research use only. We do not sell to patients.

Fucosterol Chemical Structure

Fucosterol Chemical Structure

CAS No. : 17605-67-3

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20 mg USD 315 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Fucosterol is a sterol isolated from algae, seaweed or diatoms. Fucosterol exhibits various biological activities, including antioxidant, anti-adipogenic, blood cholesterol reducing, anti-diabetic and anti-cancer activities[1][2]. Fucosterol regulates adipogenesis via inhibition of PPARα and C/EBPα expression and can be used for anti-obesity agents development research[1].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Fucosterol (0-50 μM; 7 days) suppresses the expression of PPARα and C/EBPα when compared to fully differentiated control adipocytes[1]. Fucosterol shows cytotoxicity against T47D and HT29 cell lines with IC50 values of 27.94 and 70.41 μg/ml, respectively[3].
Fucosterol decreases cell HEK293, MCF-7, and SiHa cells proliferation with IC50 values of 185.4, 43.3, and 34.0 µg/ml, respectively[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: 3T3-L1 adipocytes
Concentration: 0 μM; 25 μM; 50 μM
Incubation Time: 7 days
Result: Inhibited PPARα and C/EBPα expression.
In Vivo

Fucosterol (oral adminstratin; 30mg/kg) causes a significant decrease in serum glucose concentrations, and exhibits an inhibition of sorbitol accumulations in the lenses[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

412.69

Formula

C29H48O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

Ethanol : 16.67 mg/mL (40.39 mM; Need ultrasonic)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4231 mL 12.1156 mL 24.2313 mL
5 mM 0.4846 mL 2.4231 mL 4.8463 mL
10 mM 0.2423 mL 1.2116 mL 2.4231 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (6.06 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.06 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: ≥98.0%

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Fucosterol
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HY-N4103
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