Sitostanol  (Synonyms: Stigmastanol; 24α-Ethyl cholestanol)

Stigmastanol is a 6-amino derivative. Stigmastanol can be isolated from Hypericum riparium. Stigmastanol increases the secretion of IL-2 and IL-10. Stigmastanol reduces the maximum mitochondrial respiration of cells. Stigmastanol has beneficial effects on the weakened immune function of asthma^[1][2][3][4].

Sitostanol (1.2 μM; 24 h) does not alter mitochondrial respiration in human brown adipocytes or human myotubes, but reduces maximal mitochondrial respiration in human hepatocellular carcinoma HepG2 cells cultured in low-glucose medium^[3].
Sitostanol (1.2 μM; 48 h for Treg population) increases the secretion of Th1-type cytokines IFN-γ and IL-2, promotes the number of regulatory T cells (Treg) and IL-10 secretion, reduces the proportion of NK cells, and tends to decrease NKT cell activity in phytohaemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMCs) from asthma patients^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

416.72

C₂₉H₅₂O

83-45-4

Solid

White to off-white

CC[C@H](CC[C@@H](C)[C@]1([H])[C@]2(C)[C@](CC1)([H])[C@]3([H])CC[C@@]4([H])C[C@@H](O)CC[C@]4(C)[C@@]3([H])CC2)C(C)C

Room temperature in continental US; may vary elsewhere.

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

• [1]. Pinhas H, et al. 6-amino derivatives of stigmastanol and cholestanol. J Med Chem. 1971;14(11):1048-1049.  [Content Brief]

  [2]. Tanemossu SA, et al. Rare biscoumarin derivatives and flavonoids from Hypericum riparium. Phytochemistry. 2014;105:171-177.  [Content Brief]

  [3]. Nascimento EBM, et al. In vitro effects of sitosterol and sitostanol on mitochondrial respiration in human brown adipocytes, myotubes and hepatocytes. Eur J Nutr. 2020 Aug;59(5):2039-2045.  [Content Brief]

  [4]. Brüll F, et al. Beneficial effects of sitostanol on the attenuated immune function in asthma patients: results of an in vitro approach. PLoS One. 2012;7(10):e46895.  [Content Brief]