1. Metabolic Enzyme/Protease
  2. Endogenous Metabolite
  3. Campesterol

Campesterol (Synonyms: (24R)-5-Ergosten-3β-ol)

Cat. No.: HY-N1459 Purity: ≥98.0%
Handling Instructions

Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

For research use only. We do not sell to patients.

Campesterol Chemical Structure

Campesterol Chemical Structure

CAS No. : 474-62-4

Size Price Stock Quantity
2 mg USD 72 In-stock
Estimated Time of Arrival: December 31
5 mg USD 144 In-stock
Estimated Time of Arrival: December 31
10 mg USD 216 In-stock
Estimated Time of Arrival: December 31
25 mg USD 456 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Campesterol is a plant sterol with cholesterol lowering and anticarcinogenic effects.

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Campesterol shows a weak cytotoxicity in non-proliferating human umbilical vein endothelial cells (HUVECs). Within the non-cytotoxic concentration range, campesterol significantly inhibits the bFGF-induced proliferation and tube formation of HUVECs in a concentration-dependent manner, while it does not affect the motility of HUVECs. 50 μg/mL of campesterol decreases the cell viability up to about 56% of control(IC50 of over 50 μg/mL)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Campesterol effectively disrupts the bFGF-induced neovascularization in chick chorioallantoic membrane (CAM) in vivo[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

400.68

Formula

C₂₈H₄₈O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

Ethanol : 9.09 mg/mL (22.69 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*Campesterol is usually formulated as a suspension.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4958 mL 12.4788 mL 24.9576 mL
5 mM 0.4992 mL 2.4958 mL 4.9915 mL
10 mM 0.2496 mL 1.2479 mL 2.4958 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% EtOH    40% PEG300    5% Tween-80    45% saline

    Solubility: 0.91 mg/mL (2.27 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% EtOH    90% corn oil

    Solubility: ≥ 0.91 mg/mL (2.27 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

The effect of campesterol on the viable cell number was assessed by XTT assay. HUVECs were treated with various concentrations (10, 20, 30, 40 and 50 μg/mL) of campesterol and incubated at 37 °C in a humidified incubator for 24 h, a XTT working solution was added to each well. The cells were incubated at 37 °C for 2 h and the optical density was measured using a microplate reader at 450 nm[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References

Purity: ≥98.0%

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Campesterol
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HY-N1459
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