Fucoxanthin (Synonyms: all-trans-Fucoxanthin)

Name: Fucoxanthin
Brand: MedChemExpress
SKU: HY-N2302
Rating: 5.0 (12 reviews)

Cat. No.: HY-N2302 Purity: 99.38%: Data Sheet
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Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities.

For research use only. We do not sell to patients.

CAS No. : 3351-86-8

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
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Customer Review

Based on 12 publication(s) in Google Scholar

Other Forms of Fucoxanthin:

Fucoxanthin (Standard) In-stock

12 Publications Citing Use of MCE Fucoxanthin

Cell Proliferation/Viability Assay

Cell Migration/Invasion Assay

2D/3D Cell Culture and Differentiation

: Fucoxanthin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Sep:118:154926.; Fucoxanthin (6.25-100 μM) repressed the proliferation of GC cells at 24 h or 48 h in HGC-27 cells.

: Fucoxanthin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Sep:118:154926.; Microscopy images of cellular migration and invasion (scale bar = 100 μm). The morphology and number of migrating cells were evaluated via a Transwell assay following 24 h of treatment with different concentrations of Fucoxanthin (25, 50, and 100 μM). The invasive capacity of HLECs was determined by counting the cells that migrated across the membrane.

: Fucoxanthin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Sep:118:154926.; Fucoxanthin (25-100 μM; 24 h) inhibited tube formation in HLECs by regulating the secretion of VEGF-C in HGC-27 cells.

: Fucoxanthin purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2023 Sep:118:154926.; Immunofluorescent images (VEGFR-3, green and LYVE-1, red) of tumor lymphatic vessels in nude mice. Immunofluorescent results showed that Fucoxanthin (100-500 μM; 50 µL; i.t.; 2 weeks) significantly decreased tumor lymphangiogenesis along with the expression of LYVE-1 and VEGF-C receptor VEGFR-3.

: Fucoxanthin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2021 Jul:139:111590. [Abstract]; Cell viability of C2C12 cells in different concentrations of Fucoxanthin (FX,1-100 μM; 24 h) and dexamethasone (10 μM).

: Fucoxanthin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2021 Jul:139:111590. [Abstract]; The results showed that treatment with 10 μM dexamethasone (DEX) led to a significant reduction in MyHC expression levels, whereas treatment with 10 μM Fucoxanthin (24 h) significantly attenuated this downregulation of MyHC expression.

: Fucoxanthin purchased from MedChemExpress. Usage Cited in: Biomed Pharmacother. 2021 Jul:139:111590. [Abstract]; Morphological observation (magnification 200×; scale bar = 50 µm), MyHC staining (magnification 100×; scale bar = 50 µm) and quantification of myotubes. Ctrl = control group, DEX = dexamethasone (10 μM) treatment group, DEX + FX = dexamethasone (10 μM) combined with Fucoxanthin (10 μM; 24 h) treatment group, DEX + FX + EX527 = dexamethasone(10 μM) combined with Fucoxanthin(10 μM; 24 h) and EX-527 (SIRT1 inhibitor, 20 μM) treatment group.

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Fucoxanthin (all-trans-Fucoxanthin) is a marine carotenoid and shows anti-obesity, anti-diabetic, anti-oxidant, anti-inflammatory and anticancer activities^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]^[9].

IC₅₀ & Target

PPARγ

UCP1

PPARα

iNOS

Caspase 3

Caspase-8

Caspase 9

SOD

ERK2

In Vitro

Fucoxanthin (2.8-6.2 µM, 24 h) shows obvious bacteriostatic effect on all tested Mtb strains, with MIC values of 2.8-4.1 µM^[4].
Fucoxanthin (0-25 µM, 24 h) inhibits the proliferation of HeLa and SiHa cervical cancer cell lines and promotes cell stasis in the G0/G1 cell cycle phase^[5].
Fucoxanthin (10 µM, 12 h) inhibits the cell viability of HTLV-1-infected T cell lines by inducing G1 cell cycle arrest and apoptosis, thereby exhibiting anticancer activity^[7].
Fucoxanthin (0-100 µg/mL, 24 h) dose-dependent inhibits the expression of TNF-α, PGE2, iNOS and COX-2 proteins in RAW 264.7 cells^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[8]

Cell Line:	RAW 264.7 cells
Concentration:	0-100 µg/mL,
Incubation Time:	24 h
Result:	Inhibited LPS-induced iNOS and COX-2 protein expression in RAW 264.7 cells. Decreased NO and PEG2 concentrations in LPS-induced RAW 264.7 cells.

RT-PCR^[6]

Cell Line:	Hela and SiHa cells
Concentration:	10 µg/mL
Incubation Time:	4 h
Result:	Down-regulated N-myc mRNA expression.

In Vivo

Fucoxanthin (10-2000 mg/kg, p.o.) does not cause death or abnormal appearance in ICR mice and rats^[3].
Fucoxanthin (10-50 mg/kg/day, p.o.) can protect the cadmium-induced renal injury mouse model by improving the antioxidant capacity of mice^[9].
Fucoxanthin (0.1-10 mg/kg, i.v.) shows a dose-dependent anti-ocular inflammatory effect on EIU (endotoxin-induced uveitis) ^[8].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	6-week-old male and female Crl:CD (SD) rats, 6-week-old male and female ICR mice^[3]
Dosage:	10-2000 mg/kg/day for 28/30 days
Administration:	p.o.
Result:	No abnormal appearance or death occurred in the rats and ICR mice. Significantly increased the concentration of serum total cholesterol in rats and ICR mice.

Animal Model:	mice models subjected to cadmium-induced kidney damage, Six- to eight-week-old male Kunming mice (weight, 22–26 gram (g)/per mouse)^[9]
Dosage:	10-50 mg/kg/day for 14 days
Administration:	p.o.
Result:	Blocked the Cd-induced increase in the cadmium level. Significantly decreased the levels of blood urea nitrogen, creatinine and lipid peroxidation, and increased the levels of SOD, POD and reduced glutathione. Helped to restore mitochondrial structure and inhibit renal cell apoptosis.

Clinical Trial

Molecular Weight

658.91

Formula

C₄₂H₅₈O₆

CAS No.

3351-86-8

Appearance

Solid

Color

Purple to purplish red

SMILES

O=C(/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C([H])=[C@@]=C([C@@]1(O)C)C(C)(C[C@H](OC(C)=O)C1)C)C[C@]2(C3(C)C)[C@@](C)(C[C@@H](O)C3)O2

Structure Classification

Others

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 12.5 mg/mL (18.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5177 mL	7.5883 mL	15.1766 mL
5 mM	0.3035 mL	1.5177 mL	3.0353 mL
10 mM	0.1518 mL	0.7588 mL	1.5177 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.38%

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Data Sheet (277 KB) SDS (393 KB)

COA (242 KB) HNMR (325 KB) RP-HPLC (268 KB) MS (71 KB)

Handling Instructions (2659 KB)

References

[1]. Gammone MA, et al. Anti-obesity activity of the marine carotenoid fucoxanthin. Mar Drugs. 2015 Apr 13;13(4):2196-214. [Content Brief]

[2]. Méresse S, Fodil M, Fleury F, Chénais B. Fucoxanthin, a Marine-Derived Carotenoid from Brown Seaweeds and Microalgae: A Promising Bioactive Compound for Cancer Therapy. Int J Mol Sci. 2020;21(23):9273. [Content Brief]

[3]. Yoshimi Niwano, et al. In Vivo and in Vitro Toxicity Studies of Fucoxanthin, a Marine Carotenoid. null. 2011;0 (0):319-328.

[4]. Šudomová M, et al. A Microbiological, Toxicological, and Biochemical Study of the Effects of Fucoxanthin, a Marine Carotenoid, on Mycobacterium tuberculosis and the Enzymes Implicated in Its Cell Wall: A Link Between Mycobacterial Infection and Autoimmune Diseases. Mar Drugs. 2019 Nov 14;17(11):641. [Content Brief]

[5]. Ye G, et al. Fucoxanthin may inhibit cervical cancer cell proliferation via downregulation of HIST1H3D. J Int Med Res. 2020 Oct;48(10):300060520964011. [Content Brief]

[6]. Okuzumi J, et al. Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells. Cancer Lett. 1990 Nov 19;55(1):75-81. [Content Brief]

[7]. Ishikawa C, et al. Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. Int J Cancer. 2008 Dec 1;123(11):2702-12. [Content Brief]

[8]. Shiratori K, et al. Effects of fucoxanthin on lipopolysaccharide-induced inflammation in vitro and in vivo. Exp Eye Res. 2005 Oct;81(4):422-8. [Content Brief]

[9]. Yang H, et al. Role of Fucoxanthin towards Cadmium-induced renal impairment with the antioxidant and anti-lipid peroxide activities. Bioengineered. 2021 Dec;12(1):7235-7247. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5177 mL	7.5883 mL	15.1766 mL	37.9415 mL
	5 mM	0.3035 mL	1.5177 mL	3.0353 mL	7.5883 mL
	10 mM	0.1518 mL	0.7588 mL	1.5177 mL	3.7941 mL
	15 mM	0.1012 mL	0.5059 mL	1.0118 mL	2.5294 mL

Fucoxanthin Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Fucoxanthin (Synonyms: all-trans-Fucoxanthin)

Customer Review

Other Forms of Fucoxanthin:

Fucoxanthin Related Antibodies

12 Publications Citing Use of MCE Fucoxanthin

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All PPAR Isoform Specific Products:

View All NO Synthase Isoform Specific Products:

View All Caspase Isoform Specific Products:

View All ERK Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Fucoxanthin Related Antibodies

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Fucoxanthin Related Classifications

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