1. Metabolic Enzyme/Protease
    Apoptosis
    Immunology/Inflammation
    NF-κB
  2. Endogenous Metabolite
    Apoptosis
    Reactive Oxygen Species
  3. β-Carotene

β-Carotene (Synonyms: Provitamin A; beta-Carotene)

Cat. No.: HY-N0411 Purity: ≥98.0%
Handling Instructions

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities.

For research use only. We do not sell to patients.

β-Carotene Chemical Structure

β-Carotene Chemical Structure

CAS No. : 7235-40-7

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50 mg USD 44 In-stock
Estimated Time of Arrival: December 31
100 mg USD 62 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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1 Publications Citing Use of MCE β-Carotene

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

β-Carotene (Provitamin A), a carotenoid compound, is a naturally-occurring vitamin A precursor. β-Carotene is a modulator of reactive oxygen species (ROS), with antioxidant and antiinflammatory activities. β-Carotene may serve as an antioxidant or as a prooxidant, depending on its intrinsic properties as well as on the redox potential of the biological environment in which it acts. β-Carotene induces breast cancer cells apoptosis, with anticancer activities[1][2][3][4][5].

IC50 & Target[3]

Human Endogenous Metabolite

 

apoptosis

 

In Vitro

β-Carotene up-regulates PPAR-γ expression and ROS production in MCF-7 cancer cells[3].
β-Carotene (1-100 μM; 72 hours) remarkably decreases the survival of MCF-7 cells in a dose-dependent manner[3].
β-Carotene (50 μM; 24-72 hours) significantly enhances the expression levels of PPAR-γ mRNA and protein in a time-dependent manner[3].
β-Carotene down-regulates the COX-2 but up-regulates the p21 mRNA level and protein expression in a time dependent manner[3].
β-Carotene significantly increases the percentage of early apoptosis and the effect was partly attenuated by pre-incubation with GW9662 (HY-16578) or GSH (HY-D0187)[3].
β-Carotene induces cytochrome C release[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[5]

Cell Line: MCF-7 cells
Concentration: 1 μM, 10 μM, 20 μM, 50 μM, 100 μM
Incubation Time: 72 hours
Result: Decreased the numbers of viable cells to 70% and 50% at 20 μM and 50 μM, respectively.

RT-PCR[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated the PPAR-γ mRNA.

Western Blot Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Up-regulated PPAR-γ protein expression levels.

Apoptosis Analysis[5]

Cell Line: MCF-7 cells
Concentration: 50 μM
Incubation Time: 72 hours
Result: Induced MCF-7 cells apoptosis.
Clinical Trial
Molecular Weight

536.87

Formula

C40H56

CAS No.
SMILES

CC1(C)C(/C=C/C(C)=C/C=C/C(C)=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C2=C(C)CCCC2(C)C)=C(C)CCC1

Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

THF : 20 mg/mL (37.25 mM; Need ultrasonic)

Acetone : 5 mg/mL (9.31 mM; Need ultrasonic)

DMSO : 1 mg/mL (1.86 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8626 mL 9.3132 mL 18.6265 mL
5 mM 0.3725 mL 1.8626 mL 3.7253 mL
10 mM 0.1863 mL 0.9313 mL 1.8626 mL
*Please refer to the solubility information to select the appropriate solvent.
Purity & Documentation

Purity: ≥98.0%

References
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β-Carotene
Cat. No.:
HY-N0411
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