Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins

  • J Nat Prod. 2003 Mar;66(3):368-71. doi: 10.1021/np0203640.
Chihiro Ito  1 ,  Masataka Itoigawa ,  Yoshitaka Mishina ,  Valdir Cechinel Filho ,  Fumio Enjo ,  Harukuni Tokuda ,  Hoyoku Nishino ,  Hiroshi Furukawa
Affiliations
  • 1. Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
PMID: 12662094 DOI: 10.1021/np0203640
Abstract

Continuing our search for Cancer chemopreventive agents from natural sources, we examined constituents of the stem bark of Calophyllum brasiliense. Three new 4-substituted Coumarins named brasimarins A (2), B (3), and C (4) were isolated and characterized, along with 11 known Coumarins belonging to the calanolides or inophyllums. We also discuss the inhibitory effects of these Coumarins on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells.

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