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Cat. No.: HY-N19721

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Brasimarin B

Brasimarin B is a 4-phenylcoumarin compound found in the stem bark of Calophyllum brasiliense. Brasimarin B inhibits TPA (HY-18739)-induced EBV-EA activation in Raji cells.

For research use only. We do not sell to patients.

CAS No.: 514214-46-1
Formula: C₂₅H₂₆O₆
Molecular Weight:422.47

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Brasimarin B Chemical Structure

CAS No.: 514214-46-1

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

Brasimarin B is a 4-phenylcoumarin compound found in the stem bark of Calophyllum brasiliense. Brasimarin B inhibits TPA (HY-18739)-induced EBV-EA activation in Raji cells^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
Raji	IC₅₀	342 molar ratio Compound: 3	Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control Inhibition of TPA-induced EBV-early antigen activation in human Raji cells assessed as early antigen activation after 48 hrs relative to control	[PMID: 12662094]

In Vitro

Brasimarin B (Compound 3) (0.32-32 nmol; 48 h) inhibits TPA (HY-18739) (20 ng/mL)-induced EBV-EA activation in Raji cells with an IC₅₀ of 10.944 nmol, completely blocking activation at the highest tested concentration without significant cell viability loss^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 514214-46-1
Molecular Weight 422.47
Formula C₂₅H₂₆O₆
SMILES

CCC(C)C(C1=C(O)C(CC(O2)C(C)(O)C)=C2C(C(C3=CC=CC=C3)=C4)=C1OC4=O)=O
Structure Classification
- Phenylpropanoids
- Coumarins
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ito C, et al. Chemical constituents of Calophyllum brasiliense. 2. Structure of three new coumarins and cancer chemopreventive activity of 4-substituted coumarins. J Nat Prod. 2003;66(3):368-371. [Content Brief]

[2]. César GZ, et al. Inhibition of HIV-1 reverse transcriptase, toxicological and chemical profile of Calophyllum brasiliense extracts from Chiapas, Mexico. Fitoterapia. 2011;82(7):1027-1034. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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