23-Oxa-OSW-1
23-Oxa-OSW-1 (SBF-1), a derivative of OSW 1 (HY-101213), is a potent osterol-binding protein (OSBP) inhibitor. 23-Oxa-OSW-1 has antitumor activity.
For research use only. We do not sell to patients.
- CAS No.: 790224-37-2
- Formula: C54H82O16
- Molecular Weight:987.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HeLa | IC50 |
0.071 μM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human HeLa cells
Antiproliferative activity against human HeLa cells
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[PMID: 17127060] |
| Jurkat | IC50 |
0.015 μM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human Jurkat cells
Antiproliferative activity against human Jurkat cells
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[PMID: 17127060] |
| RKO | IC50 |
0.0007 μM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human RKO cells
Antiproliferative activity against human RKO cells
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[PMID: 17127060] |
| RKO | IC50 |
0.7 nM
Compound: 1, 23-oxa-OSW
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Antiproliferative activity against human RKO cells
Antiproliferative activity against human RKO cells
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[PMID: 17127060] |
23-Oxa-OSW-1 has antitumor activites with IC50 values of 0.0022, 0.012, and 0.094 μM in HeLa, Jurkat T, and MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 790224-37-2
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Molecular Weight 987.22
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Formula C54H82O16
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SMILES
C[C@@]1([C@](O)2[C@H](C)C(OCCCCCCCCCCCC)=O)[C@](C[C@@H]2O[C@H](OC[C@@H]3O)[C@@H]([C@H]3O[C@H](OC[C@H]4O)[C@@H]([C@H]4O)OC(C(C=C5)=CC=C5OC)=O)OC(C)=O)([H])[C@@](CC=C(C6)[C@@]7(CC[C@@H]6O)C)([H])[C@]7([H])CC1
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Synonyms
SBF-1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Shi B, et, al. OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities. J Org Chem. 2005 Dec 9;70(25):10354-67. [Content Brief]
[2]. Tan JX, et, al. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. 2022 Sep;609(7928):815-821. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
23-Oxa-OSW-1 Related Classifications
HY-148391 Related Classifications
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