Synthesis of OSW saponin analogs with modified sugar residues and their antiproliferative activities

  • Bioorg Med Chem Lett. 2007 Feb 15;17(4):1003-7. doi: 10.1016/j.bmcl.2006.11.032.
Pingping Tang  1 ,  Fatemah Mamdani ,  Xiaoyi Hu ,  Jun O Liu ,  Biao Yu
Affiliations
  • 1. State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
PMID: 17127060 DOI: 10.1016/j.bmcl.2006.11.032
Abstract

Eight monosaccharide analogs of the potent antitumor OSW saponins (2-9) were synthesized. One analog, 2-O-acetyl-alpha-l-arabinopyranoside 3, showed antiproliferative activity against the Jurkat cells (IC(50)=0.078microM) comparable to that of the disaccharide derivative (1).