790224-37-2
Chemical Structure
23-Oxa-OSW-1
Synonym(s): SBF-1
- CAS No.: 790224-37-2
- Formula:C54H82O16
- Molecular Weight:987.22
IUPAC Name: (2S,3R,4S,5R)-2-(((2S,3R,4S,5S)-3-acetoxy-2-(((3S,8R,9S,10R,13S,14S,16S,17S)-17-((S)-1-(dodecyloxy)-1-oxopropan-2-yl)-3,17-dihydroxy-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-16-yl)oxy)-5-hydroxytetrahydro-2H-pyran-4-yl)oxy)-4,5-dihydroxytetrahydro-2H-pyran-3-yl 4-methoxybenzoate
InChIKey: WGOKCDWFKWEZQT-YHHMDCOVSA-N
SMILES: C[C@@]1([C@](O)2[C@H](C)C(OCCCCCCCCCCCC)=O)[C@](C[C@@H]2O[C@H](OC[C@@H]3O)[C@@H]([C@H]3O[C@H](OC[C@H]4O)[C@@H]([C@H]4O)OC(C(C=C5)=CC=C5OC)=O)OC(C)=O)([H])[C@@](CC=C(C6)[C@@]7(CC[C@@H]6O)C)([H])[C@]7([H])CC1
Biological Activity: 23-Oxa-OSW-1 (SBF-1), a derivative of OSW 1 (HY-101213), is a potent osterol-binding protein (OSBP) inhibitor. 23-Oxa-OSW-1 has antitumor activity[1][2].
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23-Oxa-OSW-1 | 23-Oxa-OSW-1 (SBF-1), a derivative of OSW 1 (HY-101213), is a potent osterol-binding protein (OSBP) inhibitor. 23-Oxa-OSW-1 has antitumor activity. | |||||||||||||||||||||
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- [1]. Shi B, et, al. OSW saponins: facile synthesis toward a new type of structures with potent antitumor activities. J Org Chem. 2005 Dec 9;70(25):10354-67. [Content Brief]
- [2]. Tan JX, et, al. A phosphoinositide signalling pathway mediates rapid lysosomal repair. Nature. 2022 Sep;609(7928):815-821. [Content Brief]
Keywords
