1. Anti-infection
    Cell Cycle/DNA Damage
  2. Enterovirus
    DNA/RNA Synthesis
    HCV
  3. TTP-8307

TTP-8307 

Cat. No.: HY-124806
Handling Instructions

TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP).

For research use only. We do not sell to patients.

TTP-8307 Chemical Structure

TTP-8307 Chemical Structure

CAS No. : 950225-08-8

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Description

TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP)[1][2].

In Vitro

TTP-8307 targets the nonstructural protein 3A, inhibits the replication of coxsackievirus B3 (CVB3 Nancy) with EC50 of 1.2 μM. TTP-8307 inhibits the replication of coxsackievirus B3 and the three poliovirus Sabin strains, as well as coxsackieviruses A16 and A21 (EC50 of 0.85 and 5.34 μM). TTP-8307 inhibits human rhinoviruses (HRVs) 2, 29, 39, 45, 63, and 85. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307[1].
TTP-8307 inhibits OSBP-dependent viruses encephalomyocarditis virus (EMCV) and HCV[2].

Molecular Weight

436.48

Formula

C₂₇H₂₁FN₄O

CAS No.

950225-08-8

SMILES

O=C(N[[email protected]@H](C1=CC=C(F)C=C1)C)C2=CC=CC(C3=CN=C(C4=CC5=C(C=N4)C=CC=C5)N3)=C2

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

TTP-8307TTP8307TTP 8307EnterovirusDNA/RNA SynthesisHCVRhinovirusHRVHRVsHEVHEVsHepatitis C virusnonstructuralprotein3ACVB3virusOSBPsynthesisRNAInhibitorinhibitorinhibit

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TTP-8307
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