950225-08-8
Chemical Structure
TTP-8307
- CAS No.: 950225-08-8
- Formula:C27H21FN4O
- Molecular Weight:436.48
IUPAC Name: (R)-N-(1-(4-fluorophenyl)ethyl)-3-(2-(isoquinolin-3-yl)-1H-imidazol-5-yl)benzamide
InChIKey: SIBDJDZVNXVLEX-QGZVFWFLSA-N
SMILES: O=C(N[C@@H](C1=CC=C(F)C=C1)C)C2=CC=CC(C3=CN=C(C4=CC5=C(C=N4)C=CC=C5)N3)=C2
Biological Activity: TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP)[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TTP-8307 | 99.90% | TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses. TTP-8307 inhibits coxsackievirus B3 (CVB3; EC50=1.2 μM) and poliovirus by interfering with the synthesis of viral RNA. TTP-8307 exerts antiviral activity through oxysterol-binding protein (OSBP). | ||||||||||||||||||||
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- [1]. De Palma AM, et al. Mutations in the nonstructural protein 3A confer resistance to the novel enterovirus replication inhibitor TTP-8307. Antimicrob Agents Chemother. 2009 May;53(5):1850-7. [Content Brief]
- [2]. Albulescu L, et al. Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307. Antiviral Res. 2017 Apr;140:37-44. [Content Brief]
Keywords
