CK1-IN-1
Based on 1 publication(s) in Google Scholar
CK1-IN-1 (Compound 1c) is a casein kinase 1 (CK1) inhibitor with IC50 values of 15 nM and 16 nM for CK1δ and CK1ε, respectively. CK1-IN-1 inhibits p38α MAPK with an IC50 of 73 nM. CK1-IN-1 can be used to study cardiomyogenesis.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.19%
- No. CAS: 1784751-20-7
- Fòrmula: C24H15F2N3
- Peso molecular:383.39
-
Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Actividad biológica
-
Chemical Information
-
Solvente y solubilidad
- Pureza y Documentación
- Referencias
-
Help & FAQs
-
HY-15490
PF-670462 dihydrochlorideCK1δ/ε Inhibitor -
HY-100114
TA-01CK1/p38 Inhibitor -
HY-10324
D4476CK1 Inhibitor -
HY-114858
Epiblastin ACK1 Inhibitor -
HY-108642B
AMG-548 dihydrochlorideSelective p38α Inhibitor -
HY-50855
SilmitasertibCasein Kinase 2 Inhibitor -
HY-14394
TBBCK2 Inhibitor -
HY-12774
IC261CK1 Inhibitor -
HY-100011
SR-3029CK1δ/ε Inhibitor -
HY-15535
DMATCasein Kinase Inhibitor -
HY-100011R
SR-3029 (Standard)CK1δ/ε Inhibitor -
HY-15479
TTP 22Casein Kinase Inhibitor
Publications Citing Use of MedChemExpress (MCE) CK1-IN-1
More
Actividad biológica
Descripciòn
IC50 & Target
[1]|
CK1δ 15 nM (IC50) |
CK1ε 16 nM (IC50) |
p38α MAPK 73 nM (IC50) |
In Vitro
CK1-IN-1 has a stronger inhibitory activity against Casein Kinase 1 (CK1) than p38α MAPK, with IC50 values of 15 nM and 16 nM for CK1δ and CK1ε, respectively, and an IC50 value of 73 nM for p38α MAPK[1].
CK1-IN-1 (5 µM) fails to effectively promote the differentiation of human embryonic stem cells (hESC3) into cardiomyocytes and does not significantly increase the expression of Nkx2.5 green fluorescent protein[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
No. CAS 1784751-20-7
-
Appearance Solid
-
Peso molecular 383.39
-
Fòrmula C24H15F2N3
-
Color Light yellow to yellow
-
SMILES
FC1=CC=C(C2=C(C3=CC=NC=C3)NC(C4=CC=C5C=CC=CC5=C4F)=N2)C=C1
-
Envío
Room temperature in continental US; may vary elsewhere.
-
Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
Neuron
Cell-type-focused compound screen in human organoids reveals CK1 inhibition protects cone photoreceptors from death. [Abstract]2026 Jul 1;114(13):2347-2366.e12. PMID: 41916277
Solvente y solubilidad
In Vitro:
DMSO : 62.5 mg/mL (163.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : < 0.1 mg/mL (insoluble)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureza y Documentación
-
Ficha de datos (274 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.6083 mL | 13.0415 mL | 26.0831 mL | 65.2077 mL |
| 5 mM | 0.5217 mL | 2.6083 mL | 5.2166 mL | 13.0415 mL | |
| 10 mM | 0.2608 mL | 1.3042 mL | 2.6083 mL | 6.5208 mL | |
| 15 mM | 0.1739 mL | 0.8694 mL | 1.7389 mL | 4.3472 mL | |
| 20 mM | 0.1304 mL | 0.6521 mL | 1.3042 mL | 3.2604 mL | |
| 25 mM | 0.1043 mL | 0.5217 mL | 1.0433 mL | 2.6083 mL | |
| 30 mM | 0.0869 mL | 0.4347 mL | 0.8694 mL | 2.1736 mL | |
| 40 mM | 0.0652 mL | 0.3260 mL | 0.6521 mL | 1.6302 mL | |
| 50 mM | 0.0522 mL | 0.2608 mL | 0.5217 mL | 1.3042 mL | |
| 60 mM | 0.0435 mL | 0.2174 mL | 0.4347 mL | 1.0868 mL | |
| 80 mM | 0.0326 mL | 0.1630 mL | 0.3260 mL | 0.8151 mL | |
| 100 mM | 0.0261 mL | 0.1304 mL | 0.2608 mL | 0.6521 mL |
CK1-IN-1 Related Classifications
HY-111820 Related Classifications
Powered by Bioz