VT107
Based on 10 publication(s) in Google Scholar
VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer.
For research use only. We do not sell to patients.
- Purity: 99.89%
- CAS No.: 2417718-63-7
- Formula: C25H20F3N3O
- Molecular Weight:435.44
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 1 year , -20°C, 6 months
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) VT107
More- Cell Chem Biol. 2024 Oct 1:S2451-9456(24)00396-9. [Abstract]
- J Med Chem. 2022 Jul 14;65(13):9206-9229. [Abstract]
- Acta Neuropathol Commun. 2022 Dec 25;10(1):189. [Abstract]
- Life Sci Alliance. 2025 Jul 31;8(10):e202503241. [Abstract]
- Res Sq. 2026 Jun 17.
- bioRxiv. 2025 Sep 17:2025.09.15.676359. [Abstract]
- bioRxiv. 2025 Aug 10.
- bioRxiv. 2025 Mar 27:2025.03.24.644191. [Abstract]
- bioRxiv. 2024 November 12.
- bioRxiv. 2024 November 17.
Customer Validation & Images
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IF
All YAP Isoforms
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Biological Activity
TEAD[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| NCI-H226 | IC50 |
0.02 μM
Compound: VT-107
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Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
Cytotoxicity against human NCI-H226 cells assessed as cell viability at 10 uM measured for 7 days by celltiter-glo assay
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[PMID: 35763499] |
| NCI-H226 | IC50 |
0.03 μM
Compound: 6; VT107
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Antiproliferative activity against human NCI-H226 cells incubated for 120 hrs by Celltiter-glo luminescent assay
Antiproliferative activity against human NCI-H226 cells incubated for 120 hrs by Celltiter-glo luminescent assay
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[PMID: 38746898] |
VT107 (3 μmol/L; 20 hours; HEK293T cells) inhibits palmitoylation of both endogenous TEAD1 and TEAD3 proteins and is the most potent at blocking the palmitoylation of endogenous TEAD4 protein[1].
VT107 prevents palmitoylation of the TEAD1 protein. VT107 is slightly more potent than VT104 on TEAD2 and TEAD4. VT107 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1. VT107 decreases the levels of palmitoylated TEAD3 and TEAD4 and increases the levels of unpalmitoylated TEAD3 and TEAD4. VT107 blocks YAP and TAZ interaction with both TEAD1 and TEAD4. VT107 potently inhibits the proliferation of NF2-mutated/deficient cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293T cells
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Concentration:3 μmol/L
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Incubation Time:20 hours
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Result:Inhibited palmitoylation of both endogenous TEAD1 and TEAD3 proteins and was the most potent at blocking the palmitoylation of endogenous TEAD4 protein.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Mouse[1]
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Dosage:10 mg/kg (Pharmacokinetic Analysis)
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Administration:P.o.
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Result:Enantiomer analogous to VT104.
Chemical Information
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CAS No. 2417718-63-7
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Appearance Solid
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Molecular Weight 435.44
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Formula C25H20F3N3O
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Color White to off-white
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SMILES
O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC(N)=CC=C4)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 1 year -20°C 6 months
Publications (10)
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Journal Impact Factor
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Most Recent
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Cell Chem Biol
Enhancer reprogramming underlies therapeutic utility of a SMARCA2 degrader in SMARCA4 mutant cancer. [Abstract]2024 Oct 1:S2451-9456(24)00396-9. PMID: 39378885 -
J Med Chem
2022 Jul 14;65(13):9206-9229. PMID: 35763499 -
Acta Neuropathol Commun
Hydrogen peroxide induced by nerve injury promotes axon regeneration via connective tissue growth factor. [Abstract]2022 Dec 25;10(1):189. PMID: 36567321
VT107 purchased from MedChemExpress. Usage Cited in: Acta Neuropathol Commun. 2022 Dec 25;10(1):189. [Abstract]
VT107 (50 µM) dampens the H2O2-mediated increase in Ctgf levels (Fig. C, D). YAP is in green, Ctgf in red and nuclei are in blue.
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Life Sci Alliance
Pipeline to evaluate YAP-TEAD inhibitors indicates TEAD inhibition represses NF2-mutant mesothelioma. [Abstract]2025 Jul 31;8(10):e202503241. PMID: 40744733 -
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bioRxiv
Under Pressure: A unique mechanoresponsive mechanism of body site-specific keratin regulation in palmoplantar epidermis. [Abstract]2025 Sep 17:2025.09.15.676359. PMID: 41000774 -
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bioRxiv
2025 Mar 27:2025.03.24.644191. PMID: 40196670 -
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Solvent & Solubility
DMSO : 100 mg/mL (229.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution
This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (276 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2965 mL | 11.4826 mL | 22.9653 mL | 57.4132 mL |
| 5 mM | 0.4593 mL | 2.2965 mL | 4.5931 mL | 11.4826 mL | |
| 10 mM | 0.2297 mL | 1.1483 mL | 2.2965 mL | 5.7413 mL | |
| 15 mM | 0.1531 mL | 0.7655 mL | 1.5310 mL | 3.8275 mL | |
| 20 mM | 0.1148 mL | 0.5741 mL | 1.1483 mL | 2.8707 mL | |
| 25 mM | 0.0919 mL | 0.4593 mL | 0.9186 mL | 2.2965 mL | |
| 30 mM | 0.0766 mL | 0.3828 mL | 0.7655 mL | 1.9138 mL | |
| 40 mM | 0.0574 mL | 0.2871 mL | 0.5741 mL | 1.4353 mL | |
| 50 mM | 0.0459 mL | 0.2297 mL | 0.4593 mL | 1.1483 mL | |
| 60 mM | 0.0383 mL | 0.1914 mL | 0.3828 mL | 0.9569 mL | |
| 80 mM | 0.0287 mL | 0.1435 mL | 0.2871 mL | 0.7177 mL | |
| 100 mM | 0.0230 mL | 0.1148 mL | 0.2297 mL | 0.5741 mL |
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