1. Stem Cell/Wnt
  2. YAP
  3. VT107

VT107 

Cat. No.: HY-134957 Purity: 99.98%
Handling Instructions

VT-107, as an analogous to VT104, is a potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer.

For research use only. We do not sell to patients.

VT107 Chemical Structure

VT107 Chemical Structure

CAS No. : 2417718-63-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 495 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 450 In-stock
Estimated Time of Arrival: December 31
10 mg USD 800 In-stock
Estimated Time of Arrival: December 31
25 mg USD 1650 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

VT-107, as an analogous to VT104, is a potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer[1].

IC50 & Target

TEAD[1]

In Vitro

VT107 (3 μmol/L; 20 hours; HEK293T cells) inhibits palmitoylation of both endogenous TEAD1 and TEAD3 proteins and is the most potent at blocking the palmitoylation of endogenous TEAD4 protein[1].
VT107 prevents palmitoylation of the TEAD1 protein. VT107 is slightly more potent than VT104 on TEAD2 and TEAD4. VT107 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1. VT107 decreases the levels of palmitoylated TEAD3 and TEAD4 and increases the levels of unpalmitoylated TEAD3 and TEAD4. VT107 blocks YAP and TAZ interaction with both TEAD1 and TEAD4. VT107 potently inhibits the proliferation of NF2-mutated/deficient cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HEK293T cells
Concentration: 3 μmol/L
Incubation Time: 20 hours
Result: Inhibited palmitoylation of both endogenous TEAD1 and TEAD3 proteins and was the most potent at blocking the palmitoylation of endogenous TEAD4 protein.
In Vivo

VT107 (10 mg/kg; p.o.) is a enantiomer analogous to VT104[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mouse[1]
Dosage: 10 mg/kg (Pharmacokinetic Analysis)
Administration: P.o.
Result: Enantiomer analogous to VT104.
Molecular Weight

435.44

Formula

C₂₅H₂₀F₃N₃O

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
References

Purity: 99.98%

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Product Name:
VT107
Cat. No.:
HY-134957
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