2. Stem Cell/Wnt
  3. YAP
  4. VT107

VT107 

Cat. No.: HY-134957 Purity: 99.98%
COA Handling Instructions

VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer.

For research use only. We do not sell to patients.

VT107 Chemical Structure

VT107 Chemical Structure

CAS No. : 2417718-63-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 495 In-stock
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
 USD 495 In-stock
Solid
5 mg USD 450 In-stock
10 mg USD 800 In-stock
25 mg USD 1650 In-stock
50 mg USD 2600 In-stock
100 mg USD 4000 In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 3 publication(s) in Google Scholar

VT107 Related Antibodies

Top Publications Citing Use of Products

    VT107 purchased from MCE. Usage Cited in: Acta Neuropathol Commun. 2022 Dec 25;10(1):189.  [Abstract]

    VT107 (50 µM) dampens the H2O2-mediated increase in Ctgf levels (Fig. C, D). YAP is in green, Ctgf in red and nuclei are in blue.

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    VT-107, as an analogous to VT104, is an orally active and potent pan-TEAD auto-palmitoylation inhibitor. VT-107 can be used for the research of cancer[1].

    IC50 & Target

    TEAD[1]
    In Vitro

    VT107 (3 μmol/L; 20 hours; HEK293T cells) inhibits palmitoylation of both endogenous TEAD1 and TEAD3 proteins and is the most potent at blocking the palmitoylation of endogenous TEAD4 protein[1].
    ? VT107 prevents palmitoylation of the TEAD1 protein. VT107 is slightly more potent than VT104 on TEAD2 and TEAD4. VT107 results in the disappearance of palmitoylated TEAD1 with a concomitant increase in unpalmitoylated TEAD1. VT107 decreases the levels of palmitoylated TEAD3 and TEAD4 and increases the levels of unpalmitoylated TEAD3 and TEAD4. VT107 blocks YAP and TAZ interaction with both TEAD1 and TEAD4. VT107 potently inhibits the proliferation of NF2-mutated/deficient cell lines[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    VT107 Related Antibodies

    Western Blot Analysis[1]

    Cell Line: HEK293T cells
    Concentration: 3 μmol/L
    Incubation Time: 20 hours
    Result: Inhibited palmitoylation of both endogenous TEAD1 and TEAD3 proteins and was the most potent at blocking the palmitoylation of endogenous TEAD4 protein.
    In Vivo

    VT107 (10 mg/kg; p.o.) is a enantiomer analogous to VT104[1].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Mouse[1]
    Dosage: 10 mg/kg (Pharmacokinetic Analysis)
    Administration: P.o.
    Result: Enantiomer analogous to VT104.
    Molecular Weight

    435.44

    Appearance

    Solid

    Formula

    C25H20F3N3O
    CAS No.
    SMILES

    O=C(C1=CC=C2C(C3=CC=C(C(F)(F)F)C=C3)=CC=CC2=C1)N[C@H](C4=NC(N)=CC=C4)C
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 1 year
    -20°C 6 months
    Solvent & Solubility
    In Vitro: 

    DMSO : 100 mg/mL (229.65 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.2965 mL 11.4826 mL 22.9653 mL
    5 mM 0.4593 mL 2.2965 mL 4.5931 mL
    10 mM 0.2297 mL 1.1483 mL 2.2965 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.5 mg/mL (5.74 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.98%

    COA (250 KB) HNMR (103 KB) LCMS (273 KB)

    Handling Instructions (2659 KB)
    References
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    • If you have published this work, please enter the PubMed ID.
    • Your name will appear on the site.

    VT107 Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    Mass   Concentration   Volume   Molecular Weight *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
    × = ×
    C1   V1   C2   V2

    Keywords:

    VT1072417718-63-7VT 107VT-107YAPYes-associated proteinpotentselectiveproliferationtumorgrowthNF2-deficientmesotheliomaanalogousInhibitorinhibitorinhibit

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