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Cat. No.: HY-178034

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PROTAC OSBP Degrader-1

PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC₅₀ of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells. Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker
(Pink: Oxysterol-binding Protein-related Protein (ORP) ligand (HY-178035); Blue: Cereblon ligand (HY-10984); Black: linker).

For research use only. We do not sell to patients.

Formula: C₅₆H₆₈N₆O₁₂
Molecular Weight:1017.17

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (263 KB)

PROTAC OSBP Degrader-1 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

PROTAC OSBP Degrader-1 (Compound 5) is a Oxysterol-binding protein (OSBP) PROTAC degrader with a DC₅₀ of 322 nM (24 h). PROTAC OSBP Degrader-1 can rapidly penetrate into cells and induce massive recruitment of OSBP at the Trans-Golgi network. PROTAC OSBP Degrader-1 has potent anticancer activity with potent cytotoxicity against U-87 MG, A549, MCF7, HeLa and MDA-MB-231 cells^[1]. Pink: OSBP ligand (HY-178035); Blue: CRBN ligase ligand (HY-10984); Black: linker (Pink: Oxysterol-binding Protein-related Protein (ORP) ligand (HY-178035); Blue: Cereblon ligand (HY-10984); Black: linker).

All PROTACs Isoforms :

Chemical Information

Molecular Weight 1017.17
Formula C₅₆H₆₈N₆O₁₂
SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCCCCCN4N=NC(COC5=CC(/C=C/C6=CC7=C(C(OC)=C6)O[C@]8(C)CC[C@@H](O)C(C)(C)[C@@]8([H])C7)=CC(O)=C5C/C=C(C)\C)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (263 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Guimard C, et al. Elaboration and profiling of the first OSBP degrader issued from natural Schweinfurthins. Bioorg Chem. 2025 Sep;164:108909. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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