Itraconazole solution
Itraconazole solution is mainly composed of Itraconazole (HY-17514). Itraconazole (R51211) is a triazole antifungal agent and a potent and orally active Hedgehog (Hh) signaling pathway antagonist with an IC50 of ~800 nM. Itraconazole potently inhibits lanosterol 14α-demethylase (cytochrome P450 enzyme), thereby inhibits the oxidative conversion of lanosterol to ergosterol. Itraconazole has anticancer and antiangiogenic effects. Itraconazole is a oxysterol-binding protein (OSBP) inhibitor.
For research use only. We do not sell to patients.
- CAS No.: 84625-61-6
- Formula: C35H38Cl2N8O4
- Molecular Weight:705.63
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Biological Activity
Description
Chemical Information
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CAS No. 84625-61-6
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Molecular Weight 705.63
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Formula C35H38Cl2N8O4
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SMILES
ClC1=C([C@]2(CN3C=NC=N3)O[C@H](CO2)COC4=CC=C(C=C4)N5CCN(CC5)C6=CC=C(C=C6)N(C7=O)C=NN7C(CC)C)C=CC(Cl)=C1
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Synonyms
R51211 solution
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Kim, J., et al., Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell, 2010. 17(4): p. 388-99. [Content Brief]
[2]. Chong, C.R., et al., Inhibition of angiogenesis by the antifungal drug itraconazole. ACS Chem Biol, 2007. 2(4): p. 263-70. [Content Brief]
[3]. Pace JR, et al. Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic. J Med Chem. 2016 Apr 28;59(8):3635-49. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Itraconazole solution Related Classifications
HY-FL17514 Related Classifications
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