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1040

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Androgen Receptor (1) Apoptosis (3) Autophagy (4) Bacterial (3) Biochemical Assay Reagents (1) Calcium Channel (5) Drug Derivative (1) Drug Intermediate (1) Drug Metabolite (5) Endothelin Receptor (4) FAK (1) Fluorescent Dye (3) GABA Receptor (1) Influenza Virus (1) Isotope-Labeled Compounds (4) MEK (4) PROTACs (1) Reference Standards (6) Small Interfering RNA (siRNA) (1) TGF-β Receptor (4) Thrombin (3) Transmembrane Glycoprotein (2)
By Research Areas:	Cancer (13) Cardiovascular Disease (17) Infection (3) Metabolic Disease (8) Neurological Disease (1)
Oligonucleotides:	Human Pre-designed siRNA Sets (1) siRNAs (1)

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Screening Libraries

Fluorescent Dye

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Isotope-Labeled Compounds

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Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-DY1040

LysoTracker Red (solution)	Fluorescent Dye Biochemical Assay Reagents	Others
LysoTracker Red (solution) is a Red fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 577/590 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and gather on spherical organelles. It is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes . Solvent and concentration: DMSO: 1 mM

HY-D1040

Cy5.5-COOH Cyanine 5.5 carboxylic acid	Fluorescent Dye	Others
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH can be used for bioimaging and disease diagnosis .

HY-B1040

Ftaxilide 1 Publications Verification	Bacterial	Infection
Ftaxilide is a novel antituberculosis agent.

HY-N1040

13-Hydroxy-8,11,13-podocarpatriene-18-oic acid	Others	Others
13-Hydroxy-8,11,13-podocarpatriene-18-oic acid is a compound isolated from the bark of Pinus yunnanensis Franch .

HY-D1040A

CY5.5-COOH chloride Cyanine 5.5 carboxylic acid chloride	Fluorescent Dye	Others
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH chloride possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH chloride can be used for bioimaging and disease diagnosis .

HY-B0284

Nifedipine Maximum Cited Publications 28 Publications Verification BAY-a-1040	Calcium Channel Autophagy	Cardiovascular Disease Cancer
Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-158101

BMS-986365 1 Publications Verification CC-94676	PROTACs Androgen Receptor	Cancer
BMS-986365 (CC-94676) is an orally active and selective targeted androgen receptor (AR) PROTAC degrader (DC₅₀ of 10-40 nM). BMS-986365 is capable of inducing cereblon (CRBN) E3 ligase-dependent ubiquitination and degradation of the androgen receptor (AR), as well as various AR mutants. BMS-986365 shows no degradation of the close AR family members estrogen receptor (ER), progesterone receptor (PR), and glucocorticoid receptor (GR). BMS-986365 shows significant in vivo potency, degrading AR, inhibiting AR signaling, and restricting tumor growth in animal models of advanced prostate cancer. BMS-986365 can be used for the study of metastatic castration-resistant prostate cancer (mCRPC) .

HY-122844

Ifebemtinib 3 Publications Verification BI-853520; IN-10018	FAK	Cancer
Ifebemtinib (BI 853520) is an orally active and potent focal adhesion kinase (FAK) inhibitor (recombinant FAK IC₅₀=1 nM). Ifebemtinib shows anti-proliferative activity against cancer cells. Ifebemtinib inhibits FER Kinase and FES Kinase with IC₅₀s of 900 nM and 1040 nM, respectively .

HY-50295

CI-1040 20+ Cited Publications PD 184352	MEK Apoptosis	Cancer
CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC₅₀ of 17 nM for MEK1.

HY-11103

Sitaxsentan sodium 2 Publications Verification IPI 1040 sodium; TBC11251 sodium	Endothelin Receptor TGF-β Receptor	Cardiovascular Disease Metabolic Disease
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan sodium exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

HY-139558

Zapnometinib PD0184264; ATR-002	MEK Influenza Virus Bacterial	Infection Cancer
Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC₅₀ of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities .

HY-101918

*DS-1040* Tosylate**	Thrombin	Cardiovascular Disease
DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases .

HY-B0284S

Nifedipine-d6 BAY-a-1040-d₆	Calcium Channel	Cardiovascular Disease Cancer
Nifedipine-d₆ (BAY-a-1040-d₆) is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

HY-169784

PPI-1040	Drug Derivative	Metabolic Disease
PPI-1040 is an orally bioavailable vinyl ether synthetic plasmalogen. PPI-1040 acts as a precursor of plasmalogen. PPI-1040 increases plasmalogen levels in plasmalogen-deficient mice and normalizes hyperactive behaviors in these mice. In wild-type mice, PPI-1040 retains the sn-1 vinyl ether group and sn-3 phosphoethanolamine group, and is converted into endogenous ethanolamine plasmalogen. PPI-1040 can be used in studies related to rhizomelic chondrodysplasia punctata .

HY-101359

TPMPA	GABA Receptor	Neurological Disease
TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABA_C receptor (K_B = 2.1 μM), but not to interact with GABA_A (K_B = 320 μM) or GABA_B receptors (EC₅₀ = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells .

HY-B0284R

Nifedipine (Standard) BAY-a-1040 (Standard)	Reference Standards Calcium Channel Autophagy	Cardiovascular Disease Cancer
Nifedipine (Standard) is the analytical standard of Nifedipine. This product is intended for research and analytical applications. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-W019726

Dehydro Nifedipine BAY-b 4759	Drug Metabolite	Cardiovascular Disease Cancer
Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

HY-P1822

*BDC2.5 mimotope 1040-31*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-76520

Sitaxsentan IPI 1040; TBC-11251	Endothelin Receptor TGF-β Receptor	Cardiovascular Disease Metabolic Disease
Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

HY-135356

m-Nifedipine	Drug Metabolite	Cardiovascular Disease
m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies .

HY-117745

DS-1040	Thrombin	Cardiovascular Disease
DS-1040 is a low-molecular-weight imidazole derivative. DS-1040 is an inhibitor of the activated thrombin-activatable fibrinolysis (TAFIa). DS-1040 can promote fibrinolysis through suppressing TAFIa activity. DS-1040 can be studied in thrombolytic disease research .

HY-50295R

*CI-1040* (Standard)** PD 184352 (Standard)	MEK Apoptosis Reference Standards	Cancer
CI-1040 (Standard) is the analytical standard of CI-1040. This product is intended for research and analytical applications. CI-1040 (PD 184352) is an orally active, highly specific, small-molecule inhibitor of MEK with an IC50 of 17 nM for MEK1.

HY-50295A

*CI-1040* hydrochloride** PD 184352 hydrochloride	MEK Apoptosis	Cancer
CI-1040 (PD 184352) hydrochloride is an orally active, highly specific inhibitor of MEK, with an IC₅₀ of 17 nM for MEK1 .

HY-B0284S1

Nifedipine-d4 BAY-a-1040-d₄	Isotope-Labeled Compounds Calcium Channel Autophagy	Cardiovascular Disease Cancer
Nifedipine-d₄ is the deuterium labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-P1822A

*BDC2.5 mimotope 1040-31 TFA*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31 TFA, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-B0284S2

Nifedipine-13C8 BAY-a-1040-¹³C₈	Isotope-Labeled Compounds Calcium Channel Autophagy	Cardiovascular Disease
Nifedipine-13C8 is a deuterated labeled Nifedipine . Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-11103R

Sitaxsentan sodium (Standard) IPI 1040 sodium (Standard); TBC11251 sodium (Standard)	Endothelin Receptor Reference Standards TGF-β Receptor	Cardiovascular Disease Metabolic Disease
Sitaxsentan (sodium) (Standard) is the analytical standard of Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) (HY-11103). This product is intended for research and analytical applications. Sitaxsentan sodium is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan sodium exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan sodium is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan sodium can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

HY-76520S

Sitaxsentan-13C6 IPI 1040-¹³C₆ ; TBC-11251-¹³C₆	Isotope-Labeled Compounds Endothelin Receptor TGF-β Receptor	Cardiovascular Disease Metabolic Disease
Sitaxsentan- ¹³C₆ (IPI 1040- ¹³C₆) is ¹³C labeled Sitaxsentan (HY-76520). Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

HY-135356R

m-Nifedipine (Standard)	Drug Metabolite Reference Standards	Cardiovascular Disease
m-Nifedipine (Standard) is the analytical standard of m-Nifedipine. This product is intended for research and analytical applications. m-Nifedipine is an impurity of Nifedipine (BAY-a-1040). Nifedipine is a potent calcium channel blocker and agent of choice for cardiac insufficiencies .

HY-W019726R

Dehydro Nifedipine (Standard) BAY-b 4759 (Standard)	Reference Standards Drug Metabolite	Cardiovascular Disease Cancer
Dehydro Nifedipine (Standard) is the analytical standard of Dehydro Nifedipine. This product is intended for research and analytical applications. Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

HY-W019726S1

Dehydro Nifedipine-13C,d3 BAY-b 4759-¹³C,d₃	Isotope-Labeled Compounds Drug Metabolite	Cancer
Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

HY-RS16455

CDS1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
CDS1 Human Pre-designed siRNA Set A contains three designed siRNAs for CDS1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

CDS1 Human Pre-designed siRNA Set A CDS1 Human Pre-designed siRNA Set A

HY-101918R

*DS-1040* Tosylate (Standard)**	Thrombin Reference Standards	Cardiovascular Disease
DS-1040 Tosylate (Standard) is the analytical standard of DS-1040 Tosylate (HY-101918). This product is intended for research and analytical applications. DS-1040 Tosylate is an orally active, selective inhibitor of activated thrombin-activatable fibrinolysis inhibitor (TAFIa) with IC₅₀s of 5.92 nM and 8.01 nM for human and rat TAFIa. DS-1040 Tosylate is a fibrinolysis enhancer for thromboembolic diseases .

HY-179636

*DS-1040* Tosylate prodrug-1**	Drug Intermediate	Cardiovascular Disease
DS-1040 Tosylate prodrug-1 (Compound 2) is a prodrug of DS-1040 Tosylate (Compound 1) (HY-101918). DS-1040 Tosylate prodrug-1 can be used to study thromboembolic diseases .

HY-106291

Cefclidin Cefclidine; E-1040	Bacterial	Infection
Cefclidin (Cefclidine) belongs to the cephalomycin-type compound .

Cat. No.	Product Name

HY-L126

Nuclear Receptor Compound Library	1,040 compounds
Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes. Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors. MCE supplies a unique collection of 1,040 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

Nuclear Receptor Compound Library

1,040 compounds

Nuclear receptors (NR) are proteins found in cells that sense androgen and thyroid hormones and certain other molecules. They are ligand-activated transcription factors that participate in many aspects of human physiology and pathology, and regulate the expression of various important genes.

Nuclear receptors have become one of the main targets in the development of new drug strategies, providing a unique type of receptors for studying a variety of human diseases, such as breast cancers, skin disorders and diabetes. 13% of U.S. Food and Drug Administration (FDA) approved drugs target nuclear receptors.

MCE supplies a unique collection of 1,040 nuclear receptor inhibitors and activators, all of which have the identified inhibitory or activated effect on nuclear receptor. MCE Nuclear Receptor Library is a useful tool for drugs research related to cancer, skin disease and diabetes.

Cat. No.	Product Name	Type

HY-DY1040

LysoTracker Red (solution)	Fluorescent Dye
LysoTracker Red (solution) is a Red fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 577/590 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and gather on spherical organelles. It is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes . Solvent and concentration: DMSO: 1 mM

LysoTracker Red (solution)

Fluorescent Dye

LysoTracker Red (solution) is a Red fluorescently labeled lysosomal probe with a maximum excitation/emission wavelength of 577/590 nm. The structure is composed of a fluorescein group and linked weak bases, which can freely cross the cell membrane and gather on spherical organelles. It is suitable for observing the internal biosynthesis and related pathogenesis of lysosomes .
Solvent and concentration: DMSO: 1 mM

HY-D1040

Cy5.5-COOH Cyanine 5.5 carboxylic acid	Fluorescent Dye
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH can be used for bioimaging and disease diagnosis .

HY-D1040A

CY5.5-COOH chloride Cyanine 5.5 carboxylic acid chloride	Fluorescent Dye
Cy5.5-COOH (Cyanine 5.5 carboxylic acid) chloride is a fluorescent dye that emits fluorescence at 710 nm upon excitation at 650 nm. Cy5.5-COOH chloride possesses excellent spectral properties, including a narrow absorption spectrum, high sensitivity, and stability. Cy5.5-COOH chloride can be used for bioimaging and disease diagnosis .

Cat. No.	Product Name	Target	Research Area

HY-P1822

*BDC2.5 mimotope 1040-31*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-P5488

*BDC2.5 Mimotope 1040-63*	Peptides	Others
BDC2.5 Mimotope 1040-63 is a biological active peptide. (The TCR transgenic model (BDC2.5) mimitope was used in type 1 diabetes (T1D) study. T1D is an autoimmune disease in which T cells mediate damage to pancreatic islet b cells. T1D is caused by autoreactive T cell destruction of insulin-producing cells. BDC2.5 mimotope was utilized to support the study on antigen presentation of antigenic peptides to islet autoantigen-specific T cells.)

HY-P1822A

*BDC2.5 mimotope 1040-31 TFA*	Transmembrane Glycoprotein	Metabolic Disease
BDC2.5 mimotope 1040-31 TFA, a BDC2.5 TCR reactive peptide, is a strong agonistic peptide for diabetogenic T cell clone BDC2.5, and the 1040-31 peptide is specific for BDC 2.5 TCR Tg ⁺T cells .

HY-P1910

*BDC2.5 mimotope 1040-51*	Peptides	Metabolic Disease
BDC2.5 mimotope 1040-51 is a mimotope peptide for diabetogenic T cell clone BDC2.5. isolated from non-obese diabetic mice .

Cat. No.	Product Name	Chemical Structure

HY-B0284S

Nifedipine-d6
Nifedipine-d₆ (BAY-a-1040-d₆) is deuterium labeled nifedipine, and nifedipine is a potent calcium channel blocker.

HY-B0284S1

Nifedipine-d4
Nifedipine-d₄ is the deuterium labeled Nifedipine. Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-B0284S2

Nifedipine-13C8
Nifedipine-13C8 is a deuterated labeled Nifedipine . Nifedipine (BAY-a-1040) is a potent calcium channel blocker and agent of choice for cardiac insufficiencies.

HY-76520S

Sitaxsentan-13C6

Sitaxsentan- ¹³C₆ (IPI 1040- ¹³C₆) is ¹³C labeled Sitaxsentan (HY-76520). Sitaxsentan (IPI 1040 sodium; TBC11251 sodium) is a potent, selective and orally active endothelin A receptor (ETA) antagonist with an IC₅₀ of 1.4 nM and a K_i of 0.43 nM. Sitaxsentan exhibits an IC₅₀ for the ETB receptor of as high as 9800 nM. Sitaxsentan is metabolized by CYP2C9 and CYP3A4, normalizes shunt-induced endothelial abnormalities, restores BMPR signaling, and suppresses pulmonary vascular remodeling and hemodynamic deterioration. Sitaxsentan can be applied in the research of pulmonary arterial hypertension and portopulmonary hypertension .

HY-W019726S1

Dehydro Nifedipine-13C,d3
Dehydro Nifedipine-13C,d3 is a deuterated labeled Dehydro Nifedipine . Dehydro nifedipine (BAY-b 4759) is a metabolite of Nifedipine (HY-B0284). Nifedipine (BAY-a-1040) is a potent calcium channel blocker and an agent of choice for cardiac insufficiencies .

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P81305

	PP1C alpha Antibody (YA1040) Alpha isoform serine threonine protein phosphatase PP1alpha 1 catalytic subunit; Catalytic subunit; PP1A; PP1A_HUMAN; PP1alpha; PP2C ALPHA; PP2CA; Ppp1ca; Protein Phosphatase 2C Alpha Isoform; Serine threonine protein phosphatase PP1 alpha catalytic subunit; Serine threonine protein phosphatase PP1 alpha catalytic subunit protein phosphatase 1; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit.	WB, IHC-F, IHC-P, ICC/IF	Human
	PP1C alpha Antibody (YA1040) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PP1C alpha.

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