182485-36-5
182485-36-5
Chemical Structure
TPMPA
- CAS No.: 182485-36-5
- Formula:C6H12NO2P
- Molecular Weight:161.14
IUPAC Name: methyl(1,2,3,6-tetrahydropyridin-4-yl)phosphinic acid
InChIKey: MFUKVPOVVKKLRQ-UHFFFAOYSA-N
SMILES: O=P(C1=CCNCC1)(C)O
Biological Activity: TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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TPMPA | 99.9% | TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells. | ||||||||||||||||||||
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References
- [1]. Martínez-Torres A, et al. GABArho 1/GABAAalpha 1 receptor chimeras to study receptor desensitization. Proc Natl Acad Sci U S A. 2000;97(7):3562-3566. [Content Brief]
- [2]. Graham A. R. Johnston, et al. Neurologically-active compounds. WO1998058939A1
- [3]. Johnston GA. GABAc receptors: relatively simple transmitter -gated ion channels?. Trends Pharmacol Sci. 1996;17(9):319-323. [Content Brief]
