1. Membrane Transporter/Ion Channel
    Neuronal Signaling
  2. GABA Receptor
  3. TPMPA

TPMPA 

Cat. No.: HY-101359
Handling Instructions

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells.

For research use only. We do not sell to patients.

TPMPA Chemical Structure

TPMPA Chemical Structure

CAS No. : 182485-36-5

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Description

TPMPA, a hybrid of isoguvacine and 3-APMPA, is the first selective antagonist for a GABAC receptor (KB = 2.1 μM), but not to interact with GABAA (KB = 320 μM) or GABAB receptors (EC50 = 500 μM). TPMPA has the potential for the research of suppressing orientation selectivity in ganglion cells[1][2][3].

IC50 & Target

KB: 2.1 μM (GABAC)

In Vitro

TPMPA antagonizes the GABA currents of ρ1 receptors (IC50 = 1.6 μM) and those of the chimeric ρ1/α1 receptors with approximately the same potency (IC50 = 1.3 μM)[1].
TPMPA shows weak activity against rho-1 and rho-2 receptors, with the KB values of 2.0 and 15.6 μM, respectively[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

161.14

Formula

C₆H₁₂NO₂P

CAS No.
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Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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TPMPA
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