303175-44-2
303175-44-2
Chemical Structure
Zapnometinib
Synonym(s): PD0184264; ATR-002
- CAS No.: 303175-44-2
- Formula:C13H7ClF2INO2
- Molecular Weight:409.55
IUPAC Name: 2-((2-chloro-4-iodophenyl)amino)-3,4-difluorobenzoic acid
InChIKey: XCNBGWKQXRQKSA-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC=C(F)C(F)=C1NC2=CC=C(I)C=C2Cl
Biological Activity: Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zapnometinib | 99.20% | Zapnometinib (PD0184264), an active metabolite of CI-1040, is a MEK inhibitor, with an IC50 of 5.7 nM. Zapnometinib exhibits antiviral activity against influenza virus and antibacterial activities. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.76
HY-168288MEK ligand-2 -
Similarity Score 0.70
HY-10508(R)-PD 0325901CL -
Similarity Score 0.69
HY-50295CI-1040 -
Similarity Score 0.67
![3-[(2-Fluoro-4-iodophenyl)amino]isonicotinic acid Chemical Structure](//file.medchemexpress.com/product_pic/hy-66016.gif)
HY-660163-[(2-Fluoro-4-iodophenyl)amino]isonicotinic acid -
Similarity Score 0.66
HY-W616054Diclofenac impurity 6 -
Similarity Score 0.65
HY-117275Meclofenamic acid -
Similarity Score 0.64
HY-13507RLumiracoxib (Standard) -
Similarity Score 0.64
HY-124411Lobenzarit -
Similarity Score 0.63
HY-143473FabG1-IN-1 -
Explore the MedChemAI to find more analogs
![3-[(2-Fluoro-4-iodophenyl)amino]isonicotinic acid Chemical Structure](http://file.medchemexpress.com/product_pic/hy-66016.gif)
References
- [1]. Laure M, et, al. Antiviral efficacy against influenza virus and pharmacokinetic analysis of a novel MEK-inhibitor, ATR-002, in cell culture and in the mouse model. Antiviral Res. 2020 Jun;178:104806. [Content Brief]
- [2]. Hamza H, et, al. Improved in vitro Efficacy of Baloxavir Marboxil Against Influenza A Virus Infection by Combination Treatment With the MEK Inhibitor ATR-002. Front Microbiol. 2021 Feb 12;12:611958. [Content Brief]
- [3]. Bruchhagen C, et, al. Metabolic conversion of CI-1040 turns a cellular MEK-inhibitor into an antibacterial compound. Sci Rep. 2018 Jun 14;8(1):9114. [Content Brief]
