CYB5B - cytochrome b5 type B Gene

Also Known as OMB5; CYB5-M; CYPB5M

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80777

About CYB5B

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:69,424,619-69,466,264 (from NCBI)

This gene has 17 transcripts (splice variants), 224 orthologues and 1 paralogue. Ubiquitous expression in adrenal (RPKM 70.4), colon (RPKM 17.6) and 22 other tissues.

Summary

Enables heme binding activity. Contributes to nitrite reductase (NO-forming) activity. Involved in nitric oxide biosynthetic process. Located in membrane. Part of nitric-oxide synthase complex. [provided by Alliance of Genome Resources, Apr 2022]

CYB5B Products (1)

mRNA Protein Name
NM_030579.3 NP_085056.2 cytochrome b5 type B

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables heme binding IDA
IDA: Inferred from direct assay
20861021 GOA
contributes to nitrite reductase (NO-forming) activity IDA
IDA: Inferred from direct assay
24500710 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25616068 GOA
Biological Process GO Annotation Evidence References Source
involved in nitric oxide biosynthetic process IDA
IDA: Inferred from direct assay
24500710 GOA
Cellular Component GO Annotation Evidence References Source
part of nitric-oxide synthase complex IDA
IDA: Inferred from direct assay
24500710 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYB5B Protein Structure

Cyt-b5

Cyt-b5: Cytochrome b5-like Heme/Steroid binding domain (22 - 95)

  • 0
  • 100
  • 146 a.a.
Protein Preferred Names Protein Names

cytochrome b5 type B

  • cytochrome b5 type B (outer mitochondrial membrane)

CYB5B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CYB5B O43169 RETREG3 Homo sapiens Q86VR2
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 RETREG3 Homo sapiens Q86VR2
Validated Y2H
32296183
Intra
CYB5B O43169 RETREG3 Homo sapiens Q86VR2
Y2H Array
32296183
Intra
CYB5B O43169 TMEM41A Homo sapiens Q96HV5
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 TMEM41A Homo sapiens Q96HV5
Validated Y2H
32296183
Intra
CYB5B O43169 TMEM41A Homo sapiens Q96HV5
Y2H Array
32296183
Intra
CYB5B O43169 PLPP4 Homo sapiens Q5VZY2
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 PLPP4 Homo sapiens Q5VZY2
Validated Y2H
32296183
Intra
CYB5B O43169 PLPP4 Homo sapiens Q5VZY2
Y2H Array
32296183
Intra
CYB5B O43169 TMEM237 Homo sapiens Q96Q45-2
Validated Y2H
32296183
Intra
CYB5B O43169 TMEM237 Homo sapiens Q96Q45-2
Y2H Array
32296183
Intra
CYB5B O43169 TMEM237 Homo sapiens Q96Q45-2
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 TMEM35A Homo sapiens Q53FP2
Y2H Array
32296183
Intra
CYB5B O43169 TMEM35A Homo sapiens Q53FP2
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 TMEM35A Homo sapiens Q53FP2
Validated Y2H
32296183
Intra
CYB5B O43169 MFSD4B Homo sapiens Q5TF39
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 MFSD4B Homo sapiens Q5TF39
Validated Y2H
32296183
Intra
CYB5B O43169 MFSD4B Homo sapiens Q5TF39
Y2H Array
32296183
Intra
CYB5B O43169 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
CYB5B O43169 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
CYB5B O43169 AHNAK2 Homo sapiens Q8IVF2-3
Validated Y2H
32296183
Intra
CYB5B O43169 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Array
32296183
Intra
CYB5B O43169 AHNAK2 Homo sapiens Q8IVF2-3
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 STOM Homo sapiens P27105
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 STOM Homo sapiens P27105
Y2H Array
32296183
Intra
CYB5B O43169 STOM Homo sapiens P27105
Validated Y2H
32296183
Intra
CYB5B O43169 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 FNDC9 Homo sapiens Q8TBE3
Validated Y2H
32296183
Intra
CYB5B O43169 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
CYB5B O43169 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
CYB5B O43169 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
CYB5B O43169 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
CYB5B O43169 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
CYB5B O43169 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 MARCHF8 Homo sapiens Q5T0T0
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 MARCHF8 Homo sapiens Q5T0T0
Validated Y2H
32296183
Intra
CYB5B O43169 MARCHF8 Homo sapiens Q5T0T0
Y2H Array
32296183
Intra
CYB5B O43169 SDHAF4 Homo sapiens Q5VUM1
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 SDHAF4 Homo sapiens Q5VUM1
Validated Y2H
32296183
Intra
CYB5B O43169 SDHAF4 Homo sapiens Q5VUM1
Y2H Array
32296183
Intra
CYB5B O43169 MUC1 Homo sapiens P15941-11
Validated Y2H
32296183
Intra
CYB5B O43169 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
CYB5B O43169 IGSF9 Homo sapiens Q9P2J2-2
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 IGSF9 Homo sapiens Q9P2J2-2
Validated Y2H
32296183
Intra
CYB5B O43169 IGSF9 Homo sapiens Q9P2J2-2
Y2H Array
32296183
Intra
CYB5B O43169 BTNL9 Homo sapiens Q6UXG8-3
Y2H Array
32296183
Intra
CYB5B O43169 BTNL9 Homo sapiens Q6UXG8-3
Validated Y2H
32296183
Intra
CYB5B O43169 BTNL9 Homo sapiens Q6UXG8-3
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
CYB5B O43169 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
CYB5B O43169 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
CYB5B O43169 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 SLC10A6 Homo sapiens Q3KNW5
Validated Y2H
32296183
Intra
CYB5B O43169 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
CYB5B O43169 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
CYB5B O43169 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 FAM210B Homo sapiens Q96KR6
Validated Y2H
32296183
Intra
CYB5B O43169 FAM210B Homo sapiens Q96KR6
Y2H Array
32296183
Intra
CYB5B O43169 FAM210B Homo sapiens Q96KR6
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
CYB5B O43169 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
CYB5B O43169 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 TMEM86B Homo sapiens Q8N661
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 TMEM86B Homo sapiens Q8N661
Y2H Array
32296183
Intra
CYB5B O43169 TMEM86B Homo sapiens Q8N661
Validated Y2H
32296183
Intra
CYB5B O43169 NDUFAF2 Homo sapiens Q8N183
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 NDUFAF2 Homo sapiens Q8N183
Validated Y2H
32296183
Intra
CYB5B O43169 NDUFAF2 Homo sapiens Q8N183
Y2H Array
32296183
Intra
CYB5B O43169 SLC39A9 Homo sapiens Q9NUM3
Y2H Array
32296183
Intra
CYB5B O43169 SLC39A9 Homo sapiens Q9NUM3
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 SLC39A9 Homo sapiens Q9NUM3
Validated Y2H
32296183
Intra
CYB5B O43169 MFSD14B Homo sapiens Q5SR56
Validated Y2H
32296183
Intra
CYB5B O43169 MFSD14B Homo sapiens Q5SR56
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 MFSD14B Homo sapiens Q5SR56
Y2H Array
32296183
Intra
CYB5B O43169 CD33 Homo sapiens P20138
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 CD33 Homo sapiens P20138
Validated Y2H
32296183
Intra
CYB5B O43169 CD33 Homo sapiens P20138
Y2H Array
32296183
Intra
CYB5B O43169 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 GJB5 Homo sapiens O95377
Validated Y2H
32296183
Intra
CYB5B O43169 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
CYB5B O43169 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 EBP Homo sapiens Q15125
Validated Y2H
32296183
Intra
CYB5B O43169 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
CYB5B O43169 MFSD5 Homo sapiens Q6N075
Y2H Array
32296183
Intra
CYB5B O43169 MFSD5 Homo sapiens Q6N075
Validated Y2H
32296183
Intra
CYB5B O43169 MFSD5 Homo sapiens Q6N075
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 KCNK5 Homo sapiens O95279
Y2H Array
32296183
Intra
CYB5B O43169 KCNK5 Homo sapiens O95279
Validated Y2H
32296183
Intra
CYB5B O43169 KCNK5 Homo sapiens O95279
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 SYT1 Homo sapiens P21579
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 SYT1 Homo sapiens P21579
Validated Y2H
32296183
Intra
CYB5B O43169 SYT1 Homo sapiens P21579
Y2H Array
32296183
Intra
CYB5B O43169 FRMD3 Homo sapiens A2A2Y4
Y2H Array
32296183
Intra
CYB5B O43169 FRMD3 Homo sapiens A2A2Y4
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 BIK Homo sapiens Q13323
Validated Y2H
32296183
Intra
CYB5B O43169 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
CYB5B O43169 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 STX1A Homo sapiens Q16623
Validated Y2H
32296183
Intra
CYB5B O43169 STX1A Homo sapiens Q16623
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 PDZK1IP1 Homo sapiens Q13113
Validated Y2H
32296183
Intra
CYB5B O43169 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
CYB5B O43169 PHACTR3 Homo sapiens Q96KR7
Y2H Array
32296183
Intra
CYB5B O43169 PHACTR3 Homo sapiens Q96KR7
Validated Y2H
32296183
Intra
CYB5B O43169 PHACTR3 Homo sapiens Q96KR7
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 TMEM139 Homo sapiens Q8IV31
Validated Y2H
32296183
Intra
CYB5B O43169 TMEM139 Homo sapiens Q8IV31
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 TMEM139 Homo sapiens Q8IV31
Y2H Array
32296183
Intra
CYB5B O43169 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
CYB5B O43169 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 CLDN7 Homo sapiens O95471
Validated Y2H
32296183
Intra
CYB5B O43169 REEP4 Homo sapiens Q9H6H4
Validated Y2H
32296183
Intra
CYB5B O43169 REEP4 Homo sapiens Q9H6H4
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 REEP4 Homo sapiens Q9H6H4
Y2H Array
32296183
Intra
CYB5B O43169 CD79A Homo sapiens P11912
Validated Y2H
32296183
Intra
CYB5B O43169 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
CYB5B O43169 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 BNIP3L Homo sapiens O60238
Y2H Array
32296183
Intra
CYB5B O43169 BNIP3L Homo sapiens O60238
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 BNIP3L Homo sapiens O60238
Validated Y2H
32296183
Intra
CYB5B O43169 KIR2DL3 Homo sapiens P43628
Validated Y2H
32296183
Intra
CYB5B O43169 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
CYB5B O43169 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Cross
CYB5B O43169 Q99IB8-PRO_0000045601 Hepatitis C virus Q99IB8-PRO_0000045601
Anti Tag CoIP
25616068
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CYB5B Proteins

Cat. No. Product Name Accession Purity
HY-P70136 CYB5B Protein, Human (HEK293, His) AAH04373.1 (K12-C118) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Angular Cheilitis

  • Cheilosis

  • Angular Cheilosis

  • Angular Stomatitis

  • Commissural Cheilitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W010253 Benzylurea 99.94% Unkown
HY-RS03418 CYB5B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20898 Cyb5b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27415 Cyb5b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CYB5B MGD MGI:1913677
Bos taurus CYB5B VGNC VGNC:49139
Rattus norvegicus CYB5B RGD RGD:621551
Macaca mulatta CYB5B VGNC VGNC:96713
Others CYB5B NCBI